The zebrafish as a model for paediatric diseases
Article first published online: 7 SEP 2012
© 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica
Volume 102, Issue 2, pages 104–110, February 2013
How to Cite
Lohi, O., Parikka, M. and Rämet, M. (2013), The zebrafish as a model for paediatric diseases. Acta Paediatrica, 102: 104–110. doi: 10.1111/j.1651-2227.2012.02835.x
- Issue published online: 10 JAN 2013
- Article first published online: 7 SEP 2012
- Accepted manuscript online: 24 AUG 2012 10:13AM EST
- Received 22 May 2012; revised 14 August 2012; accepted 17 August 2012.
- Infectious diseases;
The rapid increase in information about genes and their associations with human diseases has highlighted the need for model organisms suitable for genetic manipulation and drug testing. The zebrafish is a valuable vertebrate animal model that offers many advantages, including the relative ease of husbandry and genetic manipulation and the capacity for high-throughput screens. In this review, we describe the zebrafish as a model for paediatric diseases, with particular emphasis on haematopoietic and infectious diseases.
Conclusion: The zebrafish has become an established vertebrate model in which to elucidate the molecular mechanisms of various human diseases.