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The zebrafish as a model for paediatric diseases

Authors

  • Olli Lohi,

    1. Paediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland
    2. Department of Paediatrics, Tampere University Hospital, Tampere, Finland
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  • Mataleena Parikka,

    1. Institute of Biomedical Technology, and BioMediTech, University of Tampere, Tampere, Finland
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  • Mika Rämet

    1. Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    2. Institute of Biomedical Technology, and BioMediTech, University of Tampere, Tampere, Finland
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M Rämet, M.D., Ph.D., Institute of Biomedical Technology, 33014 University of Tampere, Tampere, Finland. Tel: +358-50-433-6276 | Fax: +358-3-364-1471 | Email: mika.ramet@uta.fi

Abstract

The rapid increase in information about genes and their associations with human diseases has highlighted the need for model organisms suitable for genetic manipulation and drug testing. The zebrafish is a valuable vertebrate animal model that offers many advantages, including the relative ease of husbandry and genetic manipulation and the capacity for high-throughput screens. In this review, we describe the zebrafish as a model for paediatric diseases, with particular emphasis on haematopoietic and infectious diseases.

Conclusion:  The zebrafish has become an established vertebrate model in which to elucidate the molecular mechanisms of various human diseases.

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