THE OCCURRENCE AND SIGNIFICANCE OF ABNORMAL BILE DUCT EPITHELIUM IN CIRRHOSIS

Authors

  • Hemming Poulsen,

    1. Department of Pathological Anatomy and Medical Department II, Kommunehospitalet and University Clinic of Infectious Diseases, Blegdamshospitalet, Copenhagen, Denmark
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  • Per Christoffersen,

    1. Department of Pathological Anatomy and Medical Department II, Kommunehospitalet and University Clinic of Infectious Diseases, Blegdamshospitalet, Copenhagen, Denmark
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    • 2

      Patologisk Anatomisk Institut, Kommunehospitalet, 1399 Copenhagen, Denmark.

  • Odd Dietrichson,

    1. Department of Pathological Anatomy and Medical Department II, Kommunehospitalet and University Clinic of Infectious Diseases, Blegdamshospitalet, Copenhagen, Denmark
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  • Viggo Faber

    1. Department of Pathological Anatomy and Medical Department II, Kommunehospitalet and University Clinic of Infectious Diseases, Blegdamshospitalet, Copenhagen, Denmark
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Abstract

Revision of a biopsy series of 497 consecutive cases of cirrhosis revealed 31 with abnormal bile duct epithelium, corresponding to 7 per cent. It is rendered probable on the basis of morphological, clinical, biochemical, and immunological findings, that this group of cryptogenic cirrhosis has developed from chronic aggressive hepatitis. It has previously been shown, that chronic aggressive hepatitis with abnormal bile duct epithelium more quickly develops cirrhosis than chronic aggressive hepatitis without abnormal bile duct epithelium. Contrary to this finding cirrhosis with abnormal bile duct epithelium does not, during the rather short period of observation in our material (27 months) exhibit a course, that deviates from other cases of cirrhosis, as the death rate is not different from that of a larger material of cirrhosis.

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