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Revision of a biopsy series of 497 consecutive cases of cirrhosis revealed 31 with abnormal bile duct epithelium, corresponding to 7 per cent. It is rendered probable on the basis of morphological, clinical, biochemical, and immunological findings, that this group of cryptogenic cirrhosis has developed from chronic aggressive hepatitis. It has previously been shown, that chronic aggressive hepatitis with abnormal bile duct epithelium more quickly develops cirrhosis than chronic aggressive hepatitis without abnormal bile duct epithelium. Contrary to this finding cirrhosis with abnormal bile duct epithelium does not, during the rather short period of observation in our material (27 months) exhibit a course, that deviates from other cases of cirrhosis, as the death rate is not different from that of a larger material of cirrhosis.