THE EFFECT OF LONG-TERM CHALLENGE WITH ENDOTOXIN ON INFECTIOUS MINK PLASMACYTOSIS

Authors


National Veterinary Institute, P.B. 8156, Oslo-Dep., Oslo 1, Norway.

Abstract

Fifty female Sapphire kits were inoculated immediately after weaning with an organ suspension containing the agent of mink plasmacytosis. The animals were equally divided into an experimental group and a control group; animals in the first group received injections of endotoxin originating from Escherichia coli, initially twice weekly and later once weekly, each dose consisting of 1 rag. This treatment greatly enhanced the development of plasmacytosis, and after 8 months of experimentation, only 3 animals in the test group survived, whereas 10 controls were still alive. Most of the experimental mink revealed lienal and hepatic storage of amyloid, three animals had also amyloid deposits in renal glomeruli.

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