GENETIC MAPPING OF THE K1 AND K4 ANTIGENS (L) OF ESCHERICHIA COLI

Non-Allelism of K(L) Antigens with K Antigens of 08:K27(A), 08:K8(L) and 09:K57(B)

Authors

  • Ida Ørskov,

    Corresponding author
    1. Statens Seruminstitut, WHO Collaborative Centre for Reference, Copenhagen, Denmark
      5 Collaborative Centre for Reference and Research on Escherichia (WHO), Statens Seruminstitut, Amager Boulevard 80, DK-2300 Copenhagen S, Denmark.
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  • Virendra Sharma,

    1. Statens Seruminstitut, WHO Collaborative Centre for Reference, Copenhagen, Denmark
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    • 3

      Department of Bacteriology and Hygiene, College of Veterinary Sciences, Hissar, India.

    • *

      Scolar of Danida (Danish International Development Agency)

  • Frits Ørskov

    1. Research on Escherichia, Copenhagen, Denmark
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5 Collaborative Centre for Reference and Research on Escherichia (WHO), Statens Seruminstitut, Amager Boulevard 80, DK-2300 Copenhagen S, Denmark.

Abstract

Escherichia donor strains having antigen K1(L) or K4(L) transfer these K antigens to recipient cells at a genetic locus (kps A) similar to that of K10(L) and K54(L) linked to ser A. In crosses between the K10 donor strain and recipient strains O8:K8(L), O8:K27(A) and O9:K57(B) all recombinants which inherit donor K antigen also inherit K antigen of recipient. This result is interpreted as non-allelism between donor and recipient K antigens, and it is assumed that the structure of all polysaccharide K antigens of strains having O antigens O8 or O9, whether termed L, A, or B, are controlled by genes which differ in their location on the chromosome from genes controlling polysaccharide K antigens associated with most other O antigens.

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