SEARCH

SEARCH BY CITATION

Keywords:

  • Treponema pallidum;
  • antigen Tp—4;
  • common antigen;
  • cross-reactions

By electro-immunoprecipitation methods it was shown that antigen Tp—4 of Treponema pallidum, antigen TR-c of the Reiter treponeme and ‘Common Antigen’ of Pseudomonas aeruginosa are immunologically cross-reactive. This finding establishes a taxonomic relationship between T. pallidum and a wide range of bacteria. The cross-reactivity explains some false positive reactions in serodiagnostic treponemal tests for syphilis. The cross-reactivity may also play a role in a possible ‘normal’ immunity against infection with T. pallidum induced by antigens by the normal human bacterial flora.