Implant Osseointegration in Circumferential Bone Defects Treated with Latex-Derived Proteins or Autogenous Bone in Dog's Mandible
Version of Record online: 29 SEP 2009
© 2009 Wiley Periodicals, Inc.
Clinical Implant Dentistry and Related Research
Volume 14, Issue 1, pages 135–143, March 2012
How to Cite
Manfrin Arnez, M. F., Xavier, S. P., Pinto Faria, P. E., Pedrosa Júnior, W. F., Cunha, T. R., de Mendonça, R. J., Coutinho-Netto, J. and Salata, L. A. (2012), Implant Osseointegration in Circumferential Bone Defects Treated with Latex-Derived Proteins or Autogenous Bone in Dog's Mandible. Clinical Implant Dentistry and Related Research, 14: 135–143. doi: 10.1111/j.1708-8208.2009.00238.x
- Issue online: 29 SEP 2009
- Version of Record online: 29 SEP 2009
- bone regeneration;
- circumferential bone defects;
- Hevea brasiliensis;
- implant osseointegration;
- latex proteins
Background: In sites with diminished bone volume, the osseointegration of dental implants can be compromised. Innovative biomaterials have been developed to aid successful osseointegration outcomes.
Purpose: The aim of this study was to evaluate the osteogenic potential of angiogenic latex proteins for improved bone formation and osseointegration of dental implants.
Materials and Methods: Ten dogs were submitted to bilateral circumferential defects (5.0 × 6.3 mm) in the mandible. Dental implant (3.3 × 10.0 mm, TiUnite MK3™, Nobel Biocare AB, Göteborg, Sweden) was installed in the center of the defects. The gap was filled either with coagulum (Cg), autogenous bone graft (BG), or latex angiogenic proteins pool (LPP). Five animals were sacrificed after 4 weeks and 12 weeks, respectively. Implant stability was evaluated using resonance frequency analysis (Osstell Mentor™, Osstell AB, Göteborg, Sweden), and bone formation was analyzed by histological and histometric analysis.
Results: LPP showed bone regeneration similar to BG and Cg at 4 weeks and 12 weeks, respectively (p ≥ .05). Bone formation, osseointegration, and implant stability improved significantly from 4 to 12 weeks (p ≤ .05).
Conclusion: Based on methodological limitations of this study, Cg alone delivers higher bone formation in the defect as compared with BG at 12 weeks; compared with Cg and BG, the treatment with LPP exhibits no advantage in terms of osteogenic potential in this experimental model, although overall osseointegration was not affected by the treatments employed in this study.