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Four categories of resin-based dentin/enamel adhesives are currently available. These include the three-step etch-&-rinse, “one-bottle” etch-&-rinse, two-step self-etch primer systems, and “all-in-one” self-etch adhesives. In consecutive issues of the Journal, the Critical Appraisal series is presenting salient publications on research in each of the categories. The first two installments focused on the etch-&-rinse systems. The series continues with this review of papers on the two-step self-etch primer systems.