Effect of theanine, γ-glutamylethylamide, on bodyweight and fat accumulation in mice

  1. Guodong ZHENG1,
  2. Kimio BAMBA2,
  3. Tsutomu OKUBO4,
  4. Lekh RAJ JUNEJA4,
  5. Itaro OGUNI3,
  6. Kazutoshi SAYAMA2,*

Article first published online: 17 MAR 2005

DOI: 10.1111/j.1740-0929.2005.00251.x

Issue

Animal Science Journal

Animal Science Journal

Volume 76, Issue 2, pages 153–157, April 2005

Additional Information

How to Cite

ZHENG, G., BAMBA, K., OKUBO, T., RAJ JUNEJA, L., OGUNI, I. and SAYAMA, K. (2005), Effect of theanine, γ-glutamylethylamide, on bodyweight and fat accumulation in mice. Animal Science Journal, 76: 153–157. doi: 10.1111/j.1740-0929.2005.00251.x

Author Information

  1. 1

    United Graduate School of Agricultural Science, Gifu University, Gifu-shi ,

  2. 2

    Faculty of Agriculture, Shizuoka University and

  3. 3

    School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka-shi and

  4. 4

    Central Research Laboratories, Taiyo Kagaku, Yokkaichi-shi, Japan

*Kazutoshi Sayama, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka-shi, 422-8529, Japan. (Email: acksaya@agr.shizuoka.ac.jp)

Publication History

  1. Issue published online: 17 MAR 2005
  2. Article first published online: 17 MAR 2005
  3. Received 28 April 2004; accepted for publication 13 October 2004.

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Keywords:

  • anti-obesity;
  • bodyweight;
  • fat accumulation;
  • lipid metabolism;
  • theanine

ABSTRACT

To clarify the details of the anti-obesity effect of theanine, γ-glutamylethylamide, female ICR mice were fed diets containing theanine at the concentrations of 0.01, 0.02, 0.04, 0.08 and 0.16% for 16 weeks. Bodyweight and food intake in the mice were measured every 4 weeks, and several organs and intraperitoneal adipose tissues (IPAT) were weighed after the feeding. In addition, lipid levels in the serum and liver were analyzed. As a result, the bodyweight increase and weight of IPAT were significantly reduced in mice fed 0.04% theanine compared with controls, but not in mice fed other diets. The levels of triglycerides (TG) and non-esterified fatty acids in the serum and TG level in the liver in mice fed the 0.04% theanine diet were remarkably decreased. These results indicated that bodyweight increase and fat accumulation were suppressed by a limited concentration of 0.04% theanine in mice.

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