This research was funded in part by the National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK36354-01A1).
EVALUATION OF EXPERIMENTALLY INDUCED CANINE HEPATIC CIRRHOSIS USING DUPLEX DOPPLER ULTRASOUND
Version of Record online: 19 MAY 2005
Volume 31, Issue 4, pages 189–194, July 1990
How to Cite
Nyland, T. G. and Fisher, P. E. (1990), EVALUATION OF EXPERIMENTALLY INDUCED CANINE HEPATIC CIRRHOSIS USING DUPLEX DOPPLER ULTRASOUND. Veterinary Radiology, 31: 189–194. doi: 10.1111/j.1740-8261.1990.tb01809.x
- Issue online: 19 MAY 2005
- Version of Record online: 19 MAY 2005
- Received: December 13, 1988, accepted for publication April 21, 1989.
Portal blood flow was measured with duplex Doppler ultrasound in ten normal dogs and in ten dogs with hepatic cirrhosis induced by common bile duct ligation 4 weeks previously. Mean portal blood flow velocity in the 10 dogs with experimentally induced hepatic cirrhosis was markedly reduced (9.2 ± 1.70 cm/sec vs. normal 18.1 ± 7.6 cm/sec, p < 0.01). Mean portal blood flow was also significantly decreased compared to normal (17.2 ± 4.9 cc/min/kg versus normal 31.06 ± 9.1 cc/min/kg, p < 0.01) while portal vein diameter remained unchanged. The dogs with induced hepatic cirrhosis developed extensive extrahepatic portosystemic shunting that was confirmed at necropsy. It was concluded that decreased portal velocity and portal flow which resulted from hepatic cirrhosis was detectable noninvasively with Doppler ultrasound.