RADIATION THERAPY AND SURGERY FOR FIBROSARCOMA IN 33 CATS

Authors

  • Kim Cronin DVM,

    1. College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606 (Cronin, Page, Spodnick, Hardie, Price, Ruslander, Thrall), and Comprehensive Cancer Center Biostatistics and Computing, Duke University Medical Center, Durham, NC, 27710 (Dodge).
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    • Dr. Cronin's current address in University of Pennsylvania, School of Veterinary Medicine, 3850 Spruce St., Philadelphia, PA 19104.

  • Rodney L. Page DVM, MS,

    Corresponding author
    1. College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606 (Cronin, Page, Spodnick, Hardie, Price, Ruslander, Thrall), and Comprehensive Cancer Center Biostatistics and Computing, Duke University Medical Center, Durham, NC, 27710 (Dodge).
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  • Gary Spodnick DVM,

    1. College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606 (Cronin, Page, Spodnick, Hardie, Price, Ruslander, Thrall), and Comprehensive Cancer Center Biostatistics and Computing, Duke University Medical Center, Durham, NC, 27710 (Dodge).
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  • Richard Dodge MS,

    1. College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606 (Cronin, Page, Spodnick, Hardie, Price, Ruslander, Thrall), and Comprehensive Cancer Center Biostatistics and Computing, Duke University Medical Center, Durham, NC, 27710 (Dodge).
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  • Elizabeth N. HARDIE DVM, PhD,

    1. College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606 (Cronin, Page, Spodnick, Hardie, Price, Ruslander, Thrall), and Comprehensive Cancer Center Biostatistics and Computing, Duke University Medical Center, Durham, NC, 27710 (Dodge).
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  • G. SYLVESTER PRICE DVM, PhD,

    1. College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606 (Cronin, Page, Spodnick, Hardie, Price, Ruslander, Thrall), and Comprehensive Cancer Center Biostatistics and Computing, Duke University Medical Center, Durham, NC, 27710 (Dodge).
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  • David RUSLANDER DVM,

    1. College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606 (Cronin, Page, Spodnick, Hardie, Price, Ruslander, Thrall), and Comprehensive Cancer Center Biostatistics and Computing, Duke University Medical Center, Durham, NC, 27710 (Dodge).
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  • Donald E. Thrall DVM, PhD

    1. College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606 (Cronin, Page, Spodnick, Hardie, Price, Ruslander, Thrall), and Comprehensive Cancer Center Biostatistics and Computing, Duke University Medical Center, Durham, NC, 27710 (Dodge).
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Address correspondence and reprint requests to Dr. Page.

Abstract

Thirty-three cats with histologically confirmed fibrosarcomas were treated with radiation therapy followed by surgery. The median (95% confidence interval) disease free interval and overall survival were 398 (261,924) and 600 (lower limit 515) days, respectively. There were 19 treatment failures; 11 cats had only local recurrence, 4 cats developed metastatic disease, 3 cats had local recurrence followed by metastasis, and 1 cat developed simultaneous local and distant disease. Twelve cats are alive and discase free. Two cats died without evidence of treatment failure. The presence of tumor cells at the margin of resected tissue after radiation was the only variable which influenced treatment success. The median (95% confidence interval) disease free interval in 5 cats with tumor cells at the margin of the resected specimen was 112 (94,150) days versus 700 (lower limit 328) days for 26 cats with negative tumor margins, p<0.0001. We did not identify a relationship between tumor volume, number of prior tumor excisions, concomitant use of chemotherapy or various descriptors of the radiation therapy technique and disease free interval.

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