Funded by a grant from the Center for Comparative Animal Health, UCD.
COMPARISON BETWEEN THE SCINTIGRAPHIC UPTAKE AND PLASMA CLEARANCE OF 99mTc-DIETHYLENETRIAMINEPENTACETIC ACID (DTPA) FOR THE EVALUATION OF THE GLOMERULAR FILTRATION RATE IN DOGS
Version of Record online: 23 MAY 2005
Veterinary Radiology & Ultrasound
Volume 39, Issue 5, pages 470–474, September 1998
How to Cite
Barthez, P. Y., Hornof, W. J., Cowgill, L. D., Neal, L. A. and Mickel, P. (1998), COMPARISON BETWEEN THE SCINTIGRAPHIC UPTAKE AND PLASMA CLEARANCE OF 99mTc-DIETHYLENETRIAMINEPENTACETIC ACID (DTPA) FOR THE EVALUATION OF THE GLOMERULAR FILTRATION RATE IN DOGS. Veterinary Radiology & Ultrasound, 39: 470–474. doi: 10.1111/j.1740-8261.1998.tb01636.x
- Issue online: 23 MAY 2005
- Version of Record online: 23 MAY 2005
- Received August 15, 1996; accepted for publication October 13, 1997.
The scintigraphically measured percentage dose uptake of 99mTc-DTPA by the kidneys and the plasma clearance of 99mTc-DTPA have been reported to correlate well with inulin clearance. These two parameters were evaluated in seven dogs with known or suspected naturally occurring renal disease and compared to simultaneously measured renal inulin clearance. Correlation between inulin clearance and the 99mTc-DTPA plasma clearance was better (p=.0016) than the correlation between the percentage DTPA uptake by the kidney. It was concluded that measurement of 99mTc-DTPA plasma clearance is a more accurate method to estimate global glomerular filtration rate (GFR) than the percentage kidney uptake.