RESPONSE OF FELINE ORAL SQUAMOUS CELL CARCINOMA TO PALLIATIVE RADIATION THERAPY

  1. Victoria S. Bregazzi DVM1,
  2. Susan M. LaRue DVM, PhD2,*,
  3. Barbara E. Powers DVM, PhD3,
  4. Martin J. Fettman DVM, PhD1,
  5. Gregory K. Ogilvie DVM1,
  6. Stephen J. Withrow DVM1

Article first published online: 19 MAY 2005

DOI: 10.1111/j.1740-8261.2001.tb00907.x

Issue

Veterinary Radiology & Ultrasound

Veterinary Radiology & Ultrasound

Volume 42, Issue 1, pages 77–79, January 2001

Additional Information

How to Cite

Bregazzi, V. S., LaRue, S. M., Powers, B. E., Fettman, M. J., Ogilvie, G. K. and Withrow, S. J. (2001), RESPONSE OF FELINE ORAL SQUAMOUS CELL CARCINOMA TO PALLIATIVE RADIATION THERAPY. Veterinary Radiology & Ultrasound, 42: 77–79. doi: 10.1111/j.1740-8261.2001.tb00907.x

Author Information

  1. 1

    Department of Clinical Science, College of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523.

  2. 2

    Department of Radiological Health Sciences, College of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523.

  3. 3

    Department of Pathology, College of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523.

*Address correspondence and reprint requests to Dr Susan LaRue.

Publication History

  1. Issue published online: 19 MAY 2005
  2. Article first published online: 19 MAY 2005
  3. Received January 11, 2000; accepted for publication June 16, 2000.

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Keywords:

  • oral squamous cell carcinoma;
  • palliative radiation

Seven cats with advanced oral squamous cell carcinoma were treated with palliative radiotherapy. Megavoltage radiation in 8 Gray (Gy) fractions was delivered on days 0, 7, and 21 for a total dose of 24 Gy. Treatment field included the mandible, oropharynx, retropharyngeal lymph nodes, and tonsils. Adjuvant treatment with chemotherapy was variable. Age ranged from 13 to 18 years old with a median age of 15 years. Three of the seven cats (43%) did not complete treatment. Six cats were euthanized due to tumor growth and/or radiation side effects with a median survival time of 60 days (range = 42 to 97 days, mean = 63 ± 8.4 days). Radiotherapy complications or progression of disease occurred in 6 of 7 (85.7 %) cats and included adverse clinical signs, such as mucositis, serosanguinous oral discharge, pain, and dysphagia. These data suggest that coarse fractionation radiotherapy did not result in palliation in cats with inoperable oral squamous cell carcinoma.

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