CELLULAR FEATURES OF SONOGRAPHIC TARGET LESIONS OF THE LIVER AND SPLEEN IN 21 DOGS AND A CAT

Authors

  • Alessandra Cuccovillo,

    1. Department of Small Animal Medicine and Surgery. The Royal Veterinary College, University of London
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  • Christopher R. Lamb

    Corresponding author
    1. Department of Small Animal Medicine and Surgery. The Royal Veterinary College, University of London
      Address correspondence to Christopher R. Lamb, Department of Small Animal Medicine and Surgery, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK.
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Address correspondence to Christopher R. Lamb, Department of Small Animal Medicine and Surgery, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK.

Abstract

Target lesions are seen in ultrasound images of the liver or spleen as nodules or masses with a hypoechoic rim and a hyperechoic or isoechoic center. To assess the diagnostic significance of finding a target lesion, the cytologic and/or histopathologic findings were reviewed in a series of 21 dogs and a cat that had hepatic and/or splenic target lesions noted during abdominal ultrasonography. Twelve of 16 hepatic target lesions and 5 of 7 splenic target lesions were malignant. In this series, the finding of one or more target lesions in the liver or spleen had a positive predictive value for malignancy of 74%; for the finding of multiple target lesions in one organ, the positive predictive value for malignancy was 81%. Benign lesions associated with target lesions were nodular hyperplasia of the liver and spleen, pyogranulomatous hepatitis, cirrhosis, and chronic active hepatitis.

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