RENAL ULTRASONOGRAPHIC AND COMPUTED TOMOGRAPHIC APPEARANCE, VOLUME, AND FUNCTION OF CATS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

Authors

  • Jean K. Reichle DVM, MS,

    Corresponding author
    1. Department of Veterinary Clinical Sciences, Ohio State University College of Veterinary Medicine, Columbus, OH 43210-1089.
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  • Stephen P. DiBartola DVM,

    1. Department of Veterinary Clinical Sciences, Ohio State University College of Veterinary Medicine, Columbus, OH 43210-1089.
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  • Renée Léveillé DVM

    1. Department of Veterinary Clinical Sciences, Ohio State University College of Veterinary Medicine, Columbus, OH 43210-1089.
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  • Supported by the Ohio State University Development Funds.

Address correspondence and reprint requests to Dr. Jean Reichle, Animal Imaging, 1827 Pontius Avenue, West Los Angeles, CA 90025.

Abstract

The purpose of this study was to describe the ultrasonographic (US) and computed tomographic (CT) appearance of autosomal dominant polycystic kidney disease (ADPKD) in cats; to compare renal volume in cats with ADPKD (n = 5; mean age 59 ± 10 months)) and normal cats (n = 5; mean age 66 ± 10 months) using 2 imaging modalities, US and CT; and to calculate cyst volume using CT. Glomerular filtration rate (GFR) was determined by 2 methods: 99mTc-diethylene-triaminepentaacetic acid (99mTc-DPTA) scintigraphic uptake and 99mTc-DTPA plasma clearance. Sonographically, ADPKD affected kidneys were characterized by multiple anechoic to hypoechoic, round to irregularly shaped structures with variation in size. Affected kidneys had indistinct corticomedullary junctions and foci of mineralization. Intravenous (IV) contrast medium administration allowed more definitive identification of cysts with CT, and identification of distortion of renal pelves by cysts. A significant difference (Welch ANOVA, P= 0.05) was detected between the US-estimated renal volumes of normal and affected cats. No statistically significant differences were detected in CT volume (between the normal and affected cats, or between US and CT volume measurements) or the 2 GFR methods. In this group of clinically normal, middle-aged ADPKD cats, renal function was within normal limits and not significantly different than normal.

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