American College of Veterinary Radiology–Resident Research Grant, Research Advisory Committee, Department of Large Animal Clinical Sciences, Texas A&M University, Presented at the ACVR annual meeting, December 2–6, 2003, Chicago, IL.
EVALUATION OF 99MTC-DIETHYLENETRIAMINEPENTAACETIC ACID RENAL SCINTIGRAM CURVES IN NORMAL DOGS AFTER INDUCTION OF DIURESIS
Article first published online: 22 DEC 2005
Veterinary Radiology & Ultrasound
Volume 47, Issue 1, pages 103–107, January 2006
How to Cite
KUNZE, C., BAHR, A. and LEES, G. E. (2006), EVALUATION OF 99MTC-DIETHYLENETRIAMINEPENTAACETIC ACID RENAL SCINTIGRAM CURVES IN NORMAL DOGS AFTER INDUCTION OF DIURESIS. Veterinary Radiology & Ultrasound, 47: 103–107. doi: 10.1111/j.1740-8261.2005.00115.x
- Issue published online: 22 DEC 2005
- Article first published online: 22 DEC 2005
- Received January 7, 2005; accepted for publication July 2, 2005.
- glomerular filtration rate;
- renal scintigraphy;
- 99mTc-diethylenetriaminepentaacetic acid
The normal 99mTc-diethylenetriaminepentaacetic acid (DTPA) renal scintigram curve has 3 distinct phases; an arterial phase followed by progressive uptake and subsequent excretion from the kidney. In dogs with X-linked hereditary nephritis, a distinct flattening of the renal scintigram curve has been observed prior to any decline in glomerular filtration rate (GFR). The cause of this shape change is not known, however, it coincided with decreased urine-specific gravity and thus might be related to polyuria. To further evaluate this possibility, we assessed whether diuresis without concurrent renal disease could flatten the 99mTc-DTPA renal scintigram curve. GFR scintigraphy was performed in six healthy dogs once as a baseline, and again after induction of diuresis by each of four different methods. Scintigram curves were evaluated subjectively as well as quantitatively by calculation of GFR estimates, mean renal transit times, time to peak activity and half-time clearance. Complete flattening of the renal scintigram curve did not occur with diuresis alone, and therefore, flattening of the scintigram curve may serve as an early indicator of renal dysfunction. However, during diuresis after intravenous saline administration, alterations in time to peak activity and mean renal transit time may create inaccuracies in GFR estimates based on the conventional regression formula that cause a false lowering of the resultant global GFR value.