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Keywords:

  • [123I]-2-iodo-l-phenylalanine;
  • dogs;
  • gamma camera imaging;
  • synovial carcinoma;
  • tumor diagnosticum

[123I]-iodo-l-phenylalanine was successfully evaluated for gamma camera imaging in vivo in tumor-bearing athymic mice and in humans with brain tumors. Here, we report the use of this tracer in two dogs with synovial cell sarcoma of the tarsus. [123I]-iodo-l-phenylalanine was quantitatively prepared as a kit formulation using the Cu1+-assisted nucleophilic exchange. Rapid [123I]-2-iodo-l-phenylalanine tumor accumulation was observed with good tumor to background contrast and rapid clearance in these two dogs. This radiopharmaceutical is a promising alternative tumor tracer to overcome the known limitations of 18F-fluorodeoxyglucose and, when labelled with radioiodine-131, has the potential to be used for therapeutic purposes.