• accelerated therapy;
  • cats;
  • hypofractionated;
  • oral tumors;
  • squamous cell carcinoma

Nine cats with oral squamous cell carcinoma were treated with an accelerated radiation protocol (14 fractions of 3.5 Gy in 9 days). Radiation was administered twice daily with a 6 hour break between treatments. Median overall survival was 86±110 days. Median survival for cats with a partial response (n=6) was 60±7 days, while median survival for cats with a complete response (n=3) was 298±187 days (P=0.0639). The accelerated protocol was well tolerated and toxicity in the early and late period was manageable in all cats. Further modification of the protocol is warranted to extend survival.