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EFFECT OF CONTRAST MEDIA FORMULATION ON COMPUTED TOMOGRAPHY ANGIOGRAPHIC CONTRAST ENHANCEMENT

Authors

  • MIORI KISHIMOTO,

    1. Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-sen 11, Inada-cho, Obihiro, Hokkaido 080-8555, Japan,
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  • KAZUTAKA YAMADA,

    1. Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-sen 11, Inada-cho, Obihiro, Hokkaido 080-8555, Japan,
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  • RYO TSUNEDA,

    1. Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-sen 11, Inada-cho, Obihiro, Hokkaido 080-8555, Japan,
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  • JUNICHIRO SHIMIZU,

    1. Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-sen 11, Inada-cho, Obihiro, Hokkaido 080-8555, Japan,
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  • TOSHIROH IWASAKI,

    1. Department of Veterinary Internal Medicine, Tokyo University of Agriculture and Technology, Saiwai-cho, 3-5-8, Fuchu, Tokyo 183-8509, Japan
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  • YOH-ICHI MIYAKE

    1. Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-sen 11, Inada-cho, Obihiro, Hokkaido 080-8555, Japan,
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Address correspondence and reprint requests to Kazutaka Yamada, at the above address. E-mail: kyamada@obihiro.ac.jp

Abstract

The characteristics of contrast media formulation (mgI/ml, osmolarity, and viscosity) are generally not considered important in computed tomography (CT) angiography in animals. The purpose of this study was to assess the contrast effect in CT angiography as a function of contrast media formulation, with a constant iodine dose. The contrast effects of three contrast media with different iodine concentrations were compared by administering identical iodine dosages (mgI/kg). The contrast effects of the three contrast media differed, and the area under the time–attenuation curve of iohexol 350 mgI/ml, which had the highest iodine concentration, was the lowest. It was hypothesized that the contrast effect of a contrast medium decreases with higher iodine concentration because of the high amount of residual iodine present in the circulatory system from the injection site to the portion immediately before the great vessels. In addition, the influence of osmotic dilution on contrast media with high osmolarity was also considered. In conclusion, the contrast effect varies with different contrast media formulations, even when the same iodine dosage is administered.

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