This paper was be presented as a poster at the 20th Annual Symposium of the European College of Veterinary Neurology in Bern Switzerland in September 2007.
MAGNETIC RESONANCE IMAGING FINDINGS IN HISTOLOGICALLY CONFIRMED PUG DOG ENCEPHALITIS
Version of Record online: 28 AUG 2008
© Copyright 2008 by the American College of Veterinary Radiology
Veterinary Radiology & Ultrasound
Volume 49, Issue 5, pages 419–424, September–October 2008
How to Cite
FLEGEL, T., HENKE, D., BOETTCHER, I. C., AUPPERLE, H., OECHTERING, G. and MATIASEK, K. (2008), MAGNETIC RESONANCE IMAGING FINDINGS IN HISTOLOGICALLY CONFIRMED PUG DOG ENCEPHALITIS. Veterinary Radiology & Ultrasound, 49: 419–424. doi: 10.1111/j.1740-8261.2008.00400.x
- Issue online: 28 AUG 2008
- Version of Record online: 28 AUG 2008
- Received September 20, 2007; accepted for publication March 13, 2008.
- Pug dog;
- magnetic resonance imaging;
- pathologic findings;
- clinical findings
The purpose of the study was to describe magnetic resonance (MR) imaging features of histologically confirmed necrotizing encephalitis in four Pugs and to compare those findings with MR imaging characteristics of necrotizing encephalitis in other breeds. All dogs had the following common findings: lesions restricted to the forebrain, both cerebral hemispheres diffusely but asymmetrically affected, lesions affected gray and white matter resulting in loss of distinction between both, most severe lesions in occipital and parietal lobes, lesions were irregularly T2-hyperintense and T1-isointense to slightly T1-hypointense, and no cavitation. There were various degrees of contrast enhancement of brain and leptomeninges. Asymmetry of lateral ventricles and midline shift was seen in one dog each. Two dogs had brain herniation, which may have contributed to the progression of neurologic signs. Hyperintensity on T2-weighted and fluid attenuated inversion recovery images in the hippocampus and piriform lobe was consistent with excitotoxic edema, whereas similar imaging features in other forebrain areas corresponded to areas of inflammation or liquefaction on histopathology. In comparison with necrotizing encephalitis in other canine breeds, Pug dog encephalitis has some unique MR imaging features. Therefore, these characteristics cannot be applied to other breeds, nor should imaging features of necrotizing encephalitis of other canine breeds be used for interpretation of MR images in Pug dogs.