Presented in abstract form at the ACVR Annual Scientific Meeting, October 21–25, 2008, San Antonio, TX.
NORMAL THORACIC AND ABDOMINAL DISTRIBUTION OF 2-DEOXY-2-[18F]FLUORO-d-GLUCOSE (18FDG) IN ADULT CATS
Article first published online: 23 JUN 2009
© Copyright 2009 by the American College of Veterinary Radiology
Veterinary Radiology & Ultrasound
Volume 50, Issue 4, pages 436–441, July/August 2009
How to Cite
LEBLANC, A. K., WALL, J. S., MORANDI, F., KENNEl, S. J., STUCKEY, A., JAKOBY, B., TOWNSEND, D. W. and DANIEL, G. B. (2009), NORMAL THORACIC AND ABDOMINAL DISTRIBUTION OF 2-DEOXY-2-[18F]FLUORO-d-GLUCOSE (18FDG) IN ADULT CATS. Veterinary Radiology & Ultrasound, 50: 436–441. doi: 10.1111/j.1740-8261.2009.01562.x
This work was supported by the Milam Center for Nutritional and Oncologic Research at the University of Tennessee College of Veterinary Medicine.
- Issue published online: 23 JUN 2009
- Article first published online: 23 JUN 2009
- Received October 22, 2008; accepted for publication December 29, 2008.
- positron emission tomography;
- radionuclide imaging;
Positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-d-glucose (18FDG) is an important imaging modality for diagnosis and staging of human neoplastic disease. The purpose of this study is to describe the normal 18FDG uptake in adult cats. Six adult healthy female cats were used. Cats were sedated and then injected intravenously with 74.0±13.0 (mean±SD) MBq of 18FDG. General anesthesia was induced and cats were placed in ventral recumbancy on the PET scanner's bed. Static images using multiple bed positions were acquired approximately 60–90 min after injection. A transmission scan was acquired at each bed position utilizing a 57Co point source to perform attenuation and scatter correction. Regions of interest (ROIs) were drawn over the liver, right and left renal cortices, left ventricular wall, and wall of ascending and descending colonic segments. Standardized uptake values (SUV) were calculated using an established formula. Kidneys and intestinal tract had relatively intense uptake of 18FDG; liver activity was intermediate; the spleen was not identified in any of the cats. Cardiac activity was variable but intense activity was noted in the left ventricular myocardium in most cats. No appreciable lung uptake was noted. Mean±SD SUV values were calculated. This study established the normal pattern of uptake of 18FDG in adult cats and provided baseline data for comparison with future studies evaluating a variety of neoplastic and nonneoplastic diseases.