ULTRASONOGRAPHIC OBSERVATION OF SECRETIN-INDUCED PANCREATIC DUCT DILATION IN HEALTHY CATS

Authors

  • MATTHEW L. BARON,

    1. Department of Small Animal Clinical Sciences, C247 Veterinary Teaching Hospital, University of Tennessee College of Veterinary Medicine, 2407 River Drive, Knoxville, TN 37996-4550.
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  • SILKE HECHT,

    1. Department of Small Animal Clinical Sciences, C247 Veterinary Teaching Hospital, University of Tennessee College of Veterinary Medicine, 2407 River Drive, Knoxville, TN 37996-4550.
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  • ANDREA R. MATTHEWS,

    1. Department of Small Animal Clinical Sciences, C247 Veterinary Teaching Hospital, University of Tennessee College of Veterinary Medicine, 2407 River Drive, Knoxville, TN 37996-4550.
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  • JENNIFER E. STOKES

    1. Department of Small Animal Clinical Sciences, C247 Veterinary Teaching Hospital, University of Tennessee College of Veterinary Medicine, 2407 River Drive, Knoxville, TN 37996-4550.
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  • Presented at the annual meeting of the American College of Veterinary Radiology in Memphis, TN, October 20–24, 2009. This research project was funded by a resident research grant from the American College of Veterinary Radiology.

Address correspondence and reprint requests to Matthew L. Baron, at the above address. E-mail: mbaron@mail.ag.utk.edu

Abstract

Secretin is a polypeptide hormone that stimulates secretion of bicarbonate from the exocrine pancreas and, in healthy human subjects, causes transient pancreatic duct dilation observable sonographically. In humans with chronic pancreatitis, secretin administration fails to cause pancreatic duct dilation, theoretically due to the restrictive effects of periductal fibrosis. We characterized the effect of exogenous secretin administration on the width of the pancreatic duct in nine healthy domestic cats. Cats were given a commercially available secretin product (ChiRho Stim™) while the pancreatic duct was monitored sonographically. Mean pancreatic duct diameter increased from 0.77±0.33 to 1.42±0.40 mm after secretin administration (P=0.0017). The mean percent increase in pancreatic duct diameter over basal diameter for all time points up to 15 min postsecretin administration was 101.9±58.8%. Applicability of this technique to diagnose chronic pancreatitis in cats will need to be investigated.

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