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CHARACTERIZATION OF PHYSIOLOGIC 18F-FDG UPTAKE WITH PET-CT IN DOGS

Authors


  • This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (KRF-2008-314-E00250). [Correction added after online publication 28 July 2010: Grant number corrected.]

Address correspondence and reprint requests to Ki-Dong Eom, at the above address. E-mail: eomkd@konkuk.ac.kr

Abstract

We evaluated the whole body distribution of 2-deoxy-2-[18F]fluoro-d-glucose (18F-FDG) in seven beagle dogs using positron emission tomography/computed tomography. The mean and maximum standard uptake values (SUV) for various tissues were computed. The SUV of the aortic blood pool was 0.65±0.19. Moderate uptake was present in brain (3.40±1.01). Mild uptake was present in orbital muscles, soft palate, laryngeal and pharyngeal region, mandibular salivary gland, myocardium, liver, pancreas, kidney, and intestine. 18F-FDG uptake would be normally higher in these tissues because of normal physiologic activity. Mean and maximum SUV values of the eye, skeletal muscle, bone tissue, spleen, adrenal gland, stomach, tongue, gall bladder, and lung were similar to or lower than that of the aortic blood pool. These data provide a normal baseline for comparing pathologic 18F-FDG uptake.

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