MAGNETIC RESONANCE IMAGING APPARENT DIFFUSION COEFFICIENTS FOR HISTOLOGICALLY CONFIRMED INTRACRANIAL LESIONS IN DOGS
Version of Record online: 11 NOV 2010
© 2010 Veterinary Radiology & Ultrasound
Veterinary Radiology & Ultrasound
Volume 52, Issue 2, pages 142–148, March/April 2011
How to Cite
SUTHERLAND-SMITH, J., KING, R., FAISSLER, D., RUTHAZER, R. and SATO, A. (2011), MAGNETIC RESONANCE IMAGING APPARENT DIFFUSION COEFFICIENTS FOR HISTOLOGICALLY CONFIRMED INTRACRANIAL LESIONS IN DOGS. Veterinary Radiology & Ultrasound, 52: 142–148. doi: 10.1111/j.1740-8261.2010.01764.x
- Issue online: 9 MAR 2011
- Version of Record online: 11 NOV 2010
- Received April 2, 2010; accepted for publication September 27, 2010.
- apparent diffusion coefficient;
- diffusion-weighted imaging;
- histogram analysis
Diffusion-weighted imaging is an advanced magnetic resonance imaging technique that is well established in the diagnosis of nonhemorrhagic infarction in people. However, recent investigations into intracranial neoplastic and inflammatory disease in people have identified variable and overlapping results. In this retrospective study of 37 dogs with histologically confirmed intracranial disease, we investigated whether histogram analysis of quantitative apparent diffusion coefficients (ADC) can differentiate specific disease processes. Disease categories included: meningiomas, glial cell tumors, choroid plexus tumors, pituitary tumors, inflammatory brain diseases, acute nonhemorrhagic infarcts, chronic nonhemorrhagic infarcts, and hemorrhagic infarcts. A wide range of ADC value distributions were identified within the disease groups, and there were overlapping ADC values between most groups. Low ADC values indicating restricted diffusion of water were identified in acute nonhemorrhagic infarcts as expected, but were also seen in meningiomas, glial cell tumors, and granulomatous meningoencephalitis. Based on this preliminary data it is unlikely that singular quantitative ADC values can be used to determine the histological type of canine intracranial disease.