Presented at the Annual Scientific Conference for the American College of Veterinary Radiology in Asheville, NC, August 19, 2010.
THE USE OF DIFFUSION TENSOR IMAGING TO EVALUATE THE SPINAL CORD IN NORMAL AND ABNORMAL DOGS
Version of Record online: 20 JUN 2011
© 2011 Veterinary Radiology & Ultrasound
Veterinary Radiology & Ultrasound
Volume 52, Issue 5, pages 492–497, September/October 2011
How to Cite
PEASE, A. and MILLER, R. (2011), THE USE OF DIFFUSION TENSOR IMAGING TO EVALUATE THE SPINAL CORD IN NORMAL AND ABNORMAL DOGS. Veterinary Radiology & Ultrasound, 52: 492–497. doi: 10.1111/j.1740-8261.2011.01837.x
- Issue online: 16 SEP 2011
- Version of Record online: 20 JUN 2011
- Received September 17, 2010; accepted for publication May 10, 2011.
- spinal cord
Diffusion tensor imaging (DTI) is a specialized magnetic resonance sequence to determine the direction of water molecule motion. Our hypothesis was that information derived from DTI will be significantly different in dogs with a spinal cord lesion compared with a normal dog. Eleven normal dogs and six dogs with a spinal cord lesions were imaged. DTI was performed along with standard T1- and T2-weighted sequences in transverse and sagittal planes. Fractional anisotrophy and apparent diffusion coefficient (ADC) were obtained using regions of interests centered on the cranial aspect, middle cranial, middle caudal, and caudal aspects of the spinal cord. In normal dogs, the DTI sequence was characterized by normal fiber tracking with no statistical difference between the four sections of spinal cord (P>0.05). In the dogs with a spinal cord lesion, there was a significant difference in fractional anisotropy between the two groups (P=0.0003) and the ADC analysis statistical significance (P=0.048) at the caudal most site. Based on these findings, DTI is a potentially useful method to evaluate the spinal cord in dogs.