This work was supported by a Grant-in-Aid for Scientific Research (B) of Japan Society for the Promotion of Science. Part of this study was presented at the meeting of Japanese College of Veterinary Internal Medicine/Japanese Society of Veterinary Clinical Pathology in February 2010.
DECREASED GALLBLADDER EMPTYING IN DOGS WITH BILIARY SLUDGE OR GALLBLADDER MUCOCELE
Article first published online: 23 OCT 2011
© 2011 Veterinary Radiology & Ultrasound
Veterinary Radiology & Ultrasound
Volume 53, Issue 1, pages 84–91, January / February 2012
How to Cite
Tsukagoshi, T., Ohno, K., Tsukamoto, A., Fukushima, K., Takahashi, M., Nakashima, K., Fujino, Y. and Tsujimoto, H. (2012), DECREASED GALLBLADDER EMPTYING IN DOGS WITH BILIARY SLUDGE OR GALLBLADDER MUCOCELE. Veterinary Radiology & Ultrasound, 53: 84–91. doi: 10.1111/j.1740-8261.2011.01868.x
- Issue published online: 25 JAN 2012
- Article first published online: 23 OCT 2011
- Manuscript Accepted: 18 JUL 2011
- Manuscript Received: 8 DEC 2010
- Grant-in-Aid for Scientific Research (B) of Japan Society. Grant Number: KAKENHI 21380193
- ejection fraction;
- gallbladder motility;
Biliary sludge in dogs is dismissed commonly as an incidental finding. On the other hand, gallbladder mucocele is reported increasingly in dogs and can lead to biliary obstruction or gallbladder rupture. Cholestasis is suspected to play a role in development of sludge and mucoceles, though there are no data in dogs to support this. We investigated gallbladder emptying, a key factor in biliary flow, in dogs with mobile sludge, immobile sludge, or gallbladder mucocele and in healthy controls. Gallbladder ejection fraction estimated by ultrasonography was used as the index of gallbladder emptying. The ejection fraction at 60 min after eating was significantly decreased in all three abnormal groups. Moreover, all dogs with sludge or a mucocele had gallbladder distension. These changes were the greatest in the mucocele group. Thus, biliary stasis occurs not only in dogs with gallbladder mucocele but also in dogs with biliary sludge. Cholestasis may play a role in the pathogenesis or progression of these diseases in dogs.