Presented as a research report at the 27th Annual American College of Veterinary Internal Medicine Forum, Montreal, Quebec, Canada, June 2009.
DESCRIPTION AND VALIDATION OF A MAGNETIC RESONANCE IMAGING-GUIDED STEREOTACTIC BRAIN BIOPSY DEVICE IN THE DOG
Article first published online: 28 NOV 2011
© 2012 Veterinary Radiology & Ultrasound
Veterinary Radiology & Ultrasound
Volume 53, Issue 2, pages 150–156, March / April 2012
How to Cite
Chen, A. V., Wininger, F. A., Frey, S., Comeau, R. M., Bagley, R. S., Tucker, R. L., Schneider, A. R. and Gay, J. M. (2012), DESCRIPTION AND VALIDATION OF A MAGNETIC RESONANCE IMAGING-GUIDED STEREOTACTIC BRAIN BIOPSY DEVICE IN THE DOG. Veterinary Radiology & Ultrasound, 53: 150–156. doi: 10.1111/j.1740-8261.2011.01889.x
This study was not financially supported by Rogue Research. Funding was supported by the Washington State University College of Veterinary Medicine Intramural Research Grant. The biopsy device was purchased by the investigators.
- Issue published online: 19 MAR 2012
- Article first published online: 28 NOV 2011
- Manuscript Accepted: 14 SEP 2011
- Manuscript Received: 3 FEB 2011
- Washington State University College of Veterinary Medicine Intramural Research Grant
A stereotactic brain biopsy system that is magnetic resonance (MR) imaging-guided has not been validated in dogs. Our purpose was to determine the mean needle placement error in the caudate nucleus, thalamus, and midbrain of a canine cadaver brain using the modified Brainsight™ stereotactic system. Relocatable reference markers (fiducial markers) were attached to the cadaver head using a dental bite block. A T1-weighted gradient echo three-dimensional (3D) sequence was acquired using set parameters. Fiducial markers were used to register the head to the acquired MR images in reference to a 3D position sensor. This allowed the planning of trajectory path to brain targets in real time. Coordinates (X, Y, Z) were established for each target and 0.5 μl of diluted gadolinium was injected at each target using a 26-gauge needle to create a lesion. The center of the gadolinium deposition was identified on the postoperative MR images and coordinates (X′, Y′, Z′) were established. The precision of this system in bringing the needle to target (needle placement error) was calculated. Seventeen sites were targeted in the brain. The mean needle placement error for all target sites was 1.79 ± 0.87 mm. The upper bound of error for this stereotactic system was 3.31 mm. There was no statistically significant relationship between needle placement error and target depth (P = 0.23). The ease of use and precision of this stereotactic system support its development for clinical use in dogs with brain lesions >3.31 mm.