Get access

DESCRIPTION AND VALIDATION OF A MAGNETIC RESONANCE IMAGING-GUIDED STEREOTACTIC BRAIN BIOPSY DEVICE IN THE DOG

Authors

  • Annie V. Chen,

    Corresponding author
    • From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA
    Search for more papers by this author
  • Fred A. Wininger,

    1. From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA
    Current affiliation:
    1. Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO
    Search for more papers by this author
  • Stephen Frey,

    1. Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    2. Rogue Research Inc., Montreal, Quebec, Canada
    Search for more papers by this author
  • Roch M. Comeau,

    1. Rogue Research Inc., Montreal, Quebec, Canada
    Search for more papers by this author
  • Rodney S. Bagley,

    1. From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA
    Current affiliation:
    1. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA
    Search for more papers by this author
  • Russell L. Tucker,

    1. From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA
    Search for more papers by this author
  • Adam R. Schneider,

    1. From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA
    Search for more papers by this author
  • John M. Gay

    1. From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA
    Search for more papers by this author

  • Presented as a research report at the 27th Annual American College of Veterinary Internal Medicine Forum, Montreal, Quebec, Canada, June 2009.

  • This study was not financially supported by Rogue Research. Funding was supported by the Washington State University College of Veterinary Medicine Intramural Research Grant. The biopsy device was purchased by the investigators.

Address correspondence and reprint requests to Dr. Chen, at the above address. E-mail: avchen@vetmed.wsu.edu

Abstract

A stereotactic brain biopsy system that is magnetic resonance (MR) imaging-guided has not been validated in dogs. Our purpose was to determine the mean needle placement error in the caudate nucleus, thalamus, and midbrain of a canine cadaver brain using the modified Brainsight™ stereotactic system. Relocatable reference markers (fiducial markers) were attached to the cadaver head using a dental bite block. A T1-weighted gradient echo three-dimensional (3D) sequence was acquired using set parameters. Fiducial markers were used to register the head to the acquired MR images in reference to a 3D position sensor. This allowed the planning of trajectory path to brain targets in real time. Coordinates (X, Y, Z) were established for each target and 0.5 μl of diluted gadolinium was injected at each target using a 26-gauge needle to create a lesion. The center of the gadolinium deposition was identified on the postoperative MR images and coordinates (X′, Y′, Z′) were established. The precision of this system in bringing the needle to target (needle placement error) was calculated. Seventeen sites were targeted in the brain. The mean needle placement error for all target sites was 1.79 ± 0.87 mm. The upper bound of error for this stereotactic system was 3.31 mm. There was no statistically significant relationship between needle placement error and target depth (P = 0.23). The ease of use and precision of this stereotactic system support its development for clinical use in dogs with brain lesions >3.31 mm.

Get access to the full text of this article

Ancillary