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MRI CHARACTERISTICS OF CEREBRAL MICROBLEEDS IN FOUR DOGS

Authors

  • Caroline V. Fulkerson,

    Corresponding author
    • Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station
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  • Benjamin D. Young,

    1. Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station
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  • Nicolette D. Jackson,

    1. Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station
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  • Brian Porter,

    1. Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station
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  • Jonathan M. Levine

    1. Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station
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  • There were no funding sources for this project. This paper has not been previously published or presented and there is no conflict of interest.

Address correspondence and reprint requests to Caroline V. Fulkerson, Purdue University School of Veterinary Medicine, 625 Harrison Street, West Lafayette, IN 47907. E-mail: cvantass@purdue.edu

Abstract

Cerebral microbleeds in people are small foci of hemosiderin-containing macrophages in normal brain parenchyma. They are the remnant of previous hemorrhage and occur with greater frequency in older individuals. Our purpose was to describe the magnetic resonance (MR) appearance of cerebral microbleeds in four dogs. These lesions appeared as round, hypointense foci measuring ≤4 mm on T2*-gradient-recalled echo images. They were less conspicuous or absent on T2-weighting, being iso- or hypointense, and uniformly invisible on T1-weighted images. No contrast enhancement was seen in any of the cerebral microbleeds. Necropsy-derived histopathologic analysis of one brain confirmed these lesions to be chronic cerebrocortical infarcts containing hemosiderin. The MR changes seen in dogs were analogous to what has been described in people and will be helpful in distinguishing cerebral microbleeds from other brain lesions.

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