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Do antidepressants work? Statistical significance versus clinical benefits
Article first published online: 29 MAY 2008
DOI: 10.1111/j.1740-9713.2008.00286.x
© 2008 The Royal Statistical Society
Additional Information
How to Cite
Johnson, B. T. and Kirsch, I. (2008), Do antidepressants work? Statistical significance versus clinical benefits. Significance, 5: 54–58. doi: 10.1111/j.1740-9713.2008.00286.x
Publication History
- Issue published online: 29 MAY 2008
- Article first published online: 29 MAY 2008
- Abstract
- References
- Cited By
Ours has been called the Prozac generation but, earlier this year, newspaper front page headlines screamed “Antidepressants don't work”. Our authors' reanalysis of drug trials was widely reported as implying that antidepressant drugs such as Prozac are overprescribed and useless. The truth, as Blair T. Johnson and Irving Kirsch explain, is more complex, and more interesting.