Caries clinical trial of a remineralising toothpaste in radiation patients
Article first published online: 14 MAY 2008
© 2008 The Authors. Journal compilation © 2008 The Gerodontology Association and Blackwell Munksgaard Ltd
Volume 25, Issue 2, pages 76–88, June 2008
How to Cite
Papas, A., Russell, D., Singh, M., Kent, R., Triol, C. and Winston, A. (2008), Caries clinical trial of a remineralising toothpaste in radiation patients. Gerodontology, 25: 76–88. doi: 10.1111/j.1741-2358.2007.00199.x
- Issue published online: 14 MAY 2008
- Article first published online: 14 MAY 2008
- Accepted 18 July 2007
- saliva hypofunction;
- calcium phosphate
Objectives: The purpose of this study was to determine the efficacy and safety of a specially formulated remineralising toothpaste in controlling caries in a high-risk population: head and neck radiation patients.
Design: The study compared the performance of the remineralising toothpaste with a conventional fluoride dentifrice using double-blind randomisation.
Materials and methods: Test products: The products compared contained equivalent quantities of fluoride (1100 p.p.m.). The dual-phase remineralising toothpaste, Enamelon®, also delivered soluble calcium and phosphate ions, essential components of teeth, from separate phases. Both groups had all caries restored at baseline and used a fluoride rinse daily. Subjects: Fifty-seven subjects who received radiation to the head and neck causing saliva hypofunction, entered the study, while 44 completed the 10–12 month visit. Measurements: Examinations included coronal and root caries using the Pitts Diagnostic Criteria, salivary flow rate, plaque and gingival indices and microbiological counts over a 1-year period.
Results: The average net increment per year for root caries per subject was 0.04 (±.052) in subjects completing the study using the remineralising toothpaste and 1.65 (±0.51) for root caries in subjects completing the study using the conventional fluoride dentifrice. The difference was statistically significant (p = 0.03), suggesting lower net root surface increment/year for the remineralising toothpaste relative to the conventional toothpaste. No significant differences were noted on coronal surfaces.
Conclusion: The results indicate that the remineralising toothpaste provides a significant benefit in preventing and remineralising root caries in high-risk patients.