Periodontitis and Alzheimer’s disease: oral systemic link still on the rise?


Dr Hima S. Lohi, Department of Periodontics, Manipal College of Dental Sciences, Manipal University, Mangalore, Karnataka, India.
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doi: 10.1111/j.1741-2358.2012.00660.x

Periodontitis and Alzheimer’s disease: Oral systemic link still on the rise?

Over the past few years, there has been a rapid rise in the older segments of the world population, which has brought along with it a major health concern: dementia. Alzheimer’s disease, considered to be the most common cause of dementia, has become a prospect feared by the elderly. Inflammation of the brain is strongly implicated in Alzheimer’s disease which could be enhanced by systemic inflammation. Periodontitis being a chronic inflammatory condition, which can cause systemic inflammation, the question is whether chronic periodontitis can initiate or hasten the rate of progression of Alzheimer’s disease in susceptible individuals. In this article, the authors outline the proposed oral systemic link between periodontitis and Alzheimer’s disease.