The family stress model posits that contextual stressors, such as neighborhood danger, negatively influence youth adjustment, including internalizing symptoms, via disruptions in parenting and family processes. The current study examined a culturally and contextually modified family stress model in a diverse sample of Mexican-origin fathers and their children (N = 463) from the southwestern United States. Results supported the hypothesized negative influence of neighborhood danger on youth internalizing symptoms via disruptions in family cohesion. Paternal warmth did not play a role in linking contextual stress to outcomes. The role of harsh parenting was highly nuanced. Results suggest that both culture and context have the potential to moderate putative family stress model associations for specific parenting behaviors and further our understanding of the ways that culture and context may operate in models of family stress and youth outcomes.