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Keywords:

  • tritium water;
  • teratogenicity;
  • rat embryo;
  • LD50

Abstract In the purpose to learn the teratogenic effects of tritium, tritiated water of 50, 75, 100, 125 and 150mCi was injected into the abdominal cavity of pregnant rats individually on days 7, 8, 9, 10 and 11 of pregnancy, respectively, and the anomalies that developed were studied on day 18 of pregnancy. The anomalies occurred at the highest frequency in the cases administered with 100mCi on day 9 of pregnancy, the anomalies combined accounting for 81.3 % of the implanted embryos (100% of the surviving embryos). Among them, cardiovascular anomalies accounted for 68.8 % of the implanted embryos (84.6 % of the surviving embryos). The LD50 was 132mCi in cases administered on day 9 of pregnancy.