*Supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan, No. 60050046.
Teratogenicity of Tritium Water to Rat Embryos*
Article first published online: 2 MAY 2008
Volume 27, Issue 1, pages 23–29, March 1987
How to Cite
SATOW, Y., LEE, J.-Y., SAWADA, S. and NAKAMURA, N. (1987), Teratogenicity of Tritium Water to Rat Embryos. Congenital Anomalies, 27: 23–29. doi: 10.1111/j.1741-4520.1987.tb00690.x
- Issue published online: 2 MAY 2008
- Article first published online: 2 MAY 2008
- Received July 25, 1986
- tritium water;
- rat embryo;
Abstract In the purpose to learn the teratogenic effects of tritium, tritiated water of 50, 75, 100, 125 and 150mCi was injected into the abdominal cavity of pregnant rats individually on days 7, 8, 9, 10 and 11 of pregnancy, respectively, and the anomalies that developed were studied on day 18 of pregnancy. The anomalies occurred at the highest frequency in the cases administered with 100mCi on day 9 of pregnancy, the anomalies combined accounting for 81.3 % of the implanted embryos (100% of the surviving embryos). Among them, cardiovascular anomalies accounted for 68.8 % of the implanted embryos (84.6 % of the surviving embryos). The LD50 was 132mCi in cases administered on day 9 of pregnancy.