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Keywords:

  • anomaly;
  • embryo manipulation;
  • exo utero development;
  • fetal surgery;
  • histogenesis;
  • organogenesis

ABSTRACT  The mouse exo utero development system is useful for analyzing the roles of molecules or interactions between tissues in the histogenesis of organs after the mid-gestational period. In the article presented here, we review the mouse exo utero development system and its specific modifications depending on different purposes as well as its advantages over and limitations compared to other systems in the study of developmental biology and teratology.