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Application of the mouse exo utero development system in the study of developmental biology and teratology

Authors


Toshihisa Hatta, MD, PhD, Department of Anatomy, Shimane University School of Medicine, 89-1 Enya, Izumo, Shimane 693-8501, Japan. E-mail: thatta@med.shimane-u.ac.jp

Abstract

ABSTRACT  The mouse exo utero development system is useful for analyzing the roles of molecules or interactions between tissues in the histogenesis of organs after the mid-gestational period. In the article presented here, we review the mouse exo utero development system and its specific modifications depending on different purposes as well as its advantages over and limitations compared to other systems in the study of developmental biology and teratology.

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