Presented at the Seventh Annual Meeting of the Japan Society of Assisted Reproduction held in Osaka, Japan, on November 6–7, 2004.
Assisted reproductive technologies and birth defects
Article first published online: 18 MAY 2005
Volume 45, Issue 2, pages 39–43, June 2005
How to Cite
Shiota, K. and Yamada, S. (2005), Assisted reproductive technologies and birth defects. Congenital Anomalies, 45: 39–43. doi: 10.1111/j.1741-4520.2005.00061.x
- Issue published online: 18 MAY 2005
- Article first published online: 18 MAY 2005
- Received January 18, 2005; revised and accepted February 14, 2005.
- assisted reproductive technology;
- birth defect;
- in vitro fertilization;
- imprinting disorder;
- monochorionic dizygotic twin
ABSTRACT In vitro fertilization (IVF) and other assisted reproductive technologies (ART) are effective treatments for infertility and are widely provided at infertility clinics. Although IVF and related ART procedures are generally considered safe, some studies have suggested an excess occurrence of major malformations, low birth-weight and other perinatal complications in babies conceived by ART. Further, it was recently reported that IVF and intracytoplasmic sperm injection (ICSI) are associated with imprinting disorders in the offspring such as Beckwith-Wiedemann syndrome and Angelman syndrome. Here we review the human and animal studies investigating the potential risks of ART, and discuss the need for further investigation.