Second lineage of heart forming region provides new understanding of conotruncal heart defects
Article first published online: 24 DEC 2009
© 2010 The Author. Journal compilation © 2010 Japanese Teratology Society
Volume 50, Issue 1, pages 8–14, March 2010
How to Cite
Nakajima, Y. (2010), Second lineage of heart forming region provides new understanding of conotruncal heart defects. Congenital Anomalies, 50: 8–14. doi: 10.1111/j.1741-4520.2009.00267.x
- Issue published online: 24 FEB 2010
- Article first published online: 24 DEC 2009
- Received November 28, 2009; revised and accepted December 17, 2009.
- anterior/secondary heart field;
- conotruncal heart defects;
- heart development;
- outflow tract
Abnormal heart development causes various congenital heart defects. Recent cardiovascular biology studies have elucidated the morphological mechanisms involved in normal and abnormal heart development. The primitive heart tube originates from the lateral-most part of the heart forming mesoderm and mainly gives rise to the left ventricle. Then, during the cardiac looping, the outflow tract is elongated by the addition of cardiogenic cells from the both pharyngeal and splanchnic mesoderm (corresponding to anterior and secondary heart field, respectively), which originate from the mediocaudal region of the heart forming mesoderm and are later located anteriorly (rostrally) to the dorsal region of the heart tube. Therefore, the heart progenitors that contribute to the outflow tract region are distinct from those that form the left ventricle. The knowledge that there are two different lineages of heart progenitors in the four-chambered heart provides new understanding of the morphological and molecular etiology of conotruncal heart defects.