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Individual variation in organ histogenesis as a causative factor in the developmental origins of health and disease: Unnoticed congenital anomalies?

  1. Hiroki Otani1,*,
  2. Jun Udagawa1,
  3. Toshihisa Hatta2,
  4. Yukiko Kagohashi1,3,
  5. Ryuju Hashimoto1,
  6. Akihiro Matsumoto1,
  7. Fumio Satow1,
  8. Masayuki Nimura1,†

Article first published online: 24 NOV 2010

DOI: 10.1111/j.1741-4520.2010.00295.x

Issue

Congenital Anomalies

Congenital Anomalies

Volume 50, Issue 4, pages 205–211, December 2010

Additional Information

How to Cite

Otani, H., Udagawa, J., Hatta, T., Kagohashi, Y., Hashimoto, R., Matsumoto, A., Satow, F. and Nimura, M. (2010), Individual variation in organ histogenesis as a causative factor in the developmental origins of health and disease: Unnoticed congenital anomalies?. Congenital Anomalies, 50: 205–211. doi: 10.1111/j.1741-4520.2010.00295.x

Author Information

  1. 1

    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane

  2. 2

    Department of Molecular and Cell Structural Science, Kanazawa Medical University, Uchinada, Ishikawa

  3. 3

    Department of Health and Nutrition, The University of Shimane, Matsue, Japan

  1. †

    Present address: Kokoro Medical and Welfare Professional College, Nagasaki 850-0048, Japan.

*Hiroki Otani, MD, PhD, Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane 693-8501, Japan. Email: hotani@med.shimane-u.ac.jp

  1. †

    Present address: Kokoro Medical and Welfare Professional College, Nagasaki 850-0048, Japan.

Publication History

  1. Issue published online: 24 NOV 2010
  2. Article first published online: 24 NOV 2010
  3. Accepted manuscript online: 11 SEP 2010 02:23PM EST
  4. Received August 23, 2010; revised and accepted August 29, 2010.

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REFERENCES

  • Barker DJ (2000) Fetal Programming: Influences in Development and Disease in Later Life, NIH Monograph Series. Marcel Dekker, New York.
  • Barker DJ (2007) The origins of the developmental origins theory. J Intern Med 261: 412–417.
    Direct Link:
  • Barker DJ, Osmond C (1986) Infant mortality, childhood nutrition and ischemic heart disease in England and Wales. Lancet 1 (8489): 1077–1081.
  • De la Fuente M, Llorente R, Baeza I et al. (2009) Early maternal deprivation in rats: a proposed animal model for the study of developmental neuroimmunoendocrine interactions. Ann NY Acad Sci 1153: 176–183.
    Direct Link:
  • Gluckman PD, Hanson MA, Cooper C, Thornburg KL (2008) Effect of in utero and early-life conditions on adult health and disease. N Eng J Med 359: 61–73.
  • Godfrey KM, Gluckman PD, Hanson MA (2010) Developmental origins of metabolic disease: life course and intergenerational perspectives. Trends Endocrinol Metab 24: 199–205.
  • Hatta T, Moriyama K, Nakashima K, Taga T, Otani H (2002) The role of gp130 in cerebral cortical development: in vivo functional analysis in a mouse exo utero system. J Neurosci 22: 5516–5524.
  • Hatta T, Matsumoto A, Otani H (2004) Application of the mouse exo utero development system in the study of developmental biology and teratology. Congenit Anom 44: 2–8.
    Direct Link:
  • Hatta T, Matsumoto A, Ono A et al. (2006) Quantitative analyses of leukemia inhibitory factor in the cerebrospinal fluid in mouse embryos. Neuroreport 17: 1863–1866.
  • Kagohashi Y, Otani H (2010) Diet with a low n-6/n-3 essential fatty acid ratio when started immediately after the onset of overt diabetes prolongs survival of type 1 diabetes model NOD mice. Congenit Anom 50: 226–231.
  • Kagohashi Y, Udagawa J, Abiru N, Kobayashi M, Moriyama K, Otani H (2005a) Maternal factors in a model of type 1 diabetes differentially affect development of insulitis and overt diabetes in offspring. Diabetes 54: 2026–2031.
  • Kagohashi Y, Udagawa J, Moriyama K, Otani H (2005b) Maternal environment affects endogenous virus induction in the offspring of NOD mice. Congenit Anom 45: 80–84.
    Direct Link:
  • Kagohashi Y, Abiru N, Kobayashi M, Hashimoto M, Shido O, Otani H (2010) Maternal dietary n-6/n-3 fatty acid ratio affects type 1 diabetes development in the offspring of NOD mice. Congenit Anom 50: 212–220.
    Direct Link:
  • Keller G, Zimmer G, Mall G, Ritz E, Amann K (2003) Nephron number in patients with primary hypertension. N Engl J Med 348: 101–108.
  • McMillen C, Robinson JS (2005) Developmental origin of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev 85: 571–633.
  • McMullen S, Mostyn A (2009) Workshop on ‘nutritional models of the developmental origins of adult health and disease’: animal models for the study of the developmental origins of health and disease. Proc Nutr Soc 68: 306–320.
  • Merlet-Benichou C, Gilbert T, Vilar J, Moreau E, Freund N, Lelièvre-Pégorier M (1999) Nephron number: variability is the rule. Causes and consequences. Lab Invest 79: 515–527.
  • Mu Q, Udagawa J, Sun T, Otani H (2010) Possible roles of leptin in the early stage of prenatal development of the mouse cerebellum. Shimane J Med Sci 27: 1–7.
  • Muneoka K, Wanek N, Bryant SV (1986) Mouse embryos develop normally exo utero. J Exp Zool 239: 289–293.
    Direct Link:
  • Naito K, Udagawa J, Otani H (2010) Multidimensional standard curve for the development process of human fetuses. Stat Med 29: 2235–2245.
    Direct Link:
  • Nimura M, Udagawa J, Hatta T, Hashimoto R, Otani H (2006) Spatial and temporal patterns of expression of melanocortin type 2 and 5 receptors in the fetal mouse tissues and organs. Anat Embryol 211: 109–117.
  • Nimura M, Udagawa J, Otani H (2008) Adrenocorticotropic hormone affects nonapoptotic cell death of undifferentiated germ cells in fetal mouse testis. In vivo study by exo utero transplantation of corticotropic tumor cells into embryos. Congenit Anom 48: 81–86.
    Direct Link:
  • Norris JM, Yin X, Lamb MM et al. (2007) Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes. JAMA 298: 1420–1428.
  • Osna NA (2010) Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development. World J Gastrenterol 16: 1304–1313.
  • Otani H (2000) Congenital anomaly as one of the common diseases during human life-long development. To commemorate the 40th Annual Meeting of the Japanese Teratology Society. Congenit Anom 40: S128–S130.
  • Otani H (2007a) Harmonized histogenesis of the organs and intrauterine environment. Diabetes Pregnancy 7: 17–22 (in Japanese).
  • Otani H (2007b) Development of the brain as an integral part of harmonized systemic histogenesis. J Brain Sci 33: 1–6.
  • Otani H, Tanaka O, Tatewaki R, Naora H, Yoneyama T (1991) Diabetic environment and genetic predisposition as causes of congenital malformations in NOD mouse embryos. Diabetes 40: 1245–1250.
  • Otani H, Nimura M, Inoue K et al. (2004) Organogenesis and histogenesis of the urinary system. Nishinihon J Urol 66: 148–159 (in Japanese).
  • Otani H, Udagawa J, Lundh T et al. (2008) Morphometric study on the characteristic external features of normal and abnormal human embryos. Congenit Anom 48: 18–28.
    Direct Link:
  • Saito K, Takahashi T, Yaginuma N, Iwama N (1978) Islet morphometry in the diabetic pancreas of man. Tohoku J Exp Med 125: 185–197.
  • Schreuder MF, Nauta J (2007) Prenatal programming of nephron number and blood pressure. Kidney Int 72: 265–268.
  • Simamura E, Shimada H, Higashi N, Uchishiba M, Otani H, Hatta T (2010) Maternal leukemia inhibitory factor (LIF) promotes fetal neurogenesis via a LIF-ACTH-LIF signaling relay pathway. Endocrinology 151: 1853–1862.
  • Solomons NW (2009) Developmental origins of health and disease: concepts, caveats, and consequences for public health nutrition. Nutrition Rev 67 (Suppl 1): S12–S16.
    Direct Link:
  • Tanaka O (1976) Time of the appearance of cartilage centers on human embryos with special reference to its individual difference. Okajimas Folia Anat Jap 53: 173–198.
  • Tanaka O (1991) Variabilities in prenatal development of orofacial system. Anat Anz 172: 97–107.
  • Udagawa J, Hatta T, Naora H, Otani H (2000) Expression of the long form of leptin receptor (Ob-Rb) mRNA in the brain of mouse embryos and newborn mice. Brain Res 868: 251–258.
  • Udagawa J, Hashimoto R, Suzuki H et al. (2006a) The role of leptin in the development of the cerebral cortex in mouse embryos. Endocrinology 147: 647–658.
  • Udagawa J, Nimura M, Kagohashi Y, Otani H (2006b) Leptin deficiency causes pycnotic change in fetal cingulate cortical cells. Congenit Anom 46: 16–20.
    Direct Link:
  • Udagawa J, Nimura M, Otani H (2006c) Leptin affects oligodendroglial development in the mouse embryonic cerebral cortex. Neuroendocrinol Lett 27: 177–182.
  • Udagawa J, Hashimoto R, Hioki K, Otani H (2006d) The role of leptin in the development of the cortical neuron in mouse embryos. Brain Res 1120: 74–82.
  • Udagawa J, Hatta T, Hashimoto R, Otani H (2007) Roles of leptin in prenatal and perinatal brain development. Congenit Anom 47: 77–83.
    Direct Link:
  • Udagawa J, Yasuda A, Naito K, Otani H (2010) Analysis of the harmonized growth pattern of fetal organs by multidimensional scaling and hierarchical clustering. Congenit Anom (in press).
    Direct Link:
  • Wadhwa PD, Buss C, Entringer S, Swanson JM (2009) Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms. Semin Reprod Med 27: 358–368.
  • Waterland RA, Michels KB (2007) Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr 27: 363–388.
  • Yamada M, Hatta T, Otani H (2008) Mouse exo utero development system: protocol and troubleshooting. Congenit Anom 48: 183–187.
    Direct Link:
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