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Influence of age on exophthalmos and thyrotrophin receptor antibodies in 123 untreated patients with Graves’ disease and 560 normal control subjects

Authors


Correspondence to: Dr Nobuyuki Takasu, University of the Ryukyus. Email: takasun@med.u-ryukyu.ac.jp

Abstract

Objective:The influence of age on exophthalmos and thyrotrophin receptor antibodies (TRAb) was studied in untreated patients with Graves’ disease (GD). Exophthalmos measurement is useful for GD diagnosis in elderly Japanese patients.

Subjects and methods:Protrusions of the eyes (exophthalmic values: EV) and TRAb were studied in 123 untreated patients with GD and 560 controls. Patients with GD and controls were divided into seven age groups. The receiver operating characteristic (ROC) analysis was done to evaluate the clinical usefulness of EV for GD diagnosis.

Findings:The differences of EV between patients with GD and controls were significant in those aged 60 years and over (≥ 60 years). ROC analysis showed that the sensitivity and specificity of EV were high in elderly groups (≥ 60 years), but not in the others (< 60 years).

Conclusion:Exophthalmic values have clinical usefulness for GD diagnosis in elderly Japanese. An EV has a diagnostic value for GD in elderly patients (≥ 60 years).

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