Disseminated tuberculosis complicating anti-TNF-α treatment


*D. Papaioannides, el. Venizelou 13, 19004 Spata, Greece
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Email: dipapaio@otenet.gr


An unusually large number of cases of tuberculosis, often of miliary or disseminated form, have been reported in patients receiving infliximab therapy for rheumatoid arthritis or Crohn's disease. We describe a patient with rheumatoid arthritis who was treated with infliximab and became systemically ill with Mycobacterium tuberculosis-disseminated infection. Patients who are candidates for treatment with tumour necrosis factor-alfa inhibitors should be evaluated for the presence of latent or active M. tuberculosis infection.