Disclosures The authors state that they have no interests which might be perceived as posing a conflict or bias.
Melatonin: therapeutic and clinical utilization
Article first published online: 13 FEB 2007
International Journal of Clinical Practice
Volume 61, Issue 5, pages 835–845, May 2007
How to Cite
Altun, A. and Ugur-Altun, B. (2007), Melatonin: therapeutic and clinical utilization. International Journal of Clinical Practice, 61: 835–845. doi: 10.1111/j.1742-1241.2006.01191.x
- Issue published online: 16 MAR 2007
- Article first published online: 13 FEB 2007
- Paper received June 2006, accepted September 2006
Melatonin, acting through melatonin receptors, is involved in numerous physiological processes including circadian entrainment, blood pressure regulation, oncogenesis, retinal physiology, seasonal reproduction, ovarian physiology, immune function and most recently in inducing osteoblast differentiation. Moreover, melatonin was proved to be a potent-free radical scavenger and a broad-spectrum antioxidant. More research is required into the effects of therapeutically modulating the melatoninergic system on circadian haemodynamics and rhythm under varying physiopathological conditions and the possible impact on morbidity and mortality in humans.