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Melatonin: therapeutic and clinical utilization


  • Disclosures The authors state that they have no interests which might be perceived as posing a conflict or bias.

Armagan Altun, Head of Cardiology Department, Medical School, Trakya University, Edirne 22030, Turkey
Tel.: + 90 284 2357642 (int. 4310-4311)
Fax: + 90 284 2352730


Melatonin, acting through melatonin receptors, is involved in numerous physiological processes including circadian entrainment, blood pressure regulation, oncogenesis, retinal physiology, seasonal reproduction, ovarian physiology, immune function and most recently in inducing osteoblast differentiation. Moreover, melatonin was proved to be a potent-free radical scavenger and a broad-spectrum antioxidant. More research is required into the effects of therapeutically modulating the melatoninergic system on circadian haemodynamics and rhythm under varying physiopathological conditions and the possible impact on morbidity and mortality in humans.