Tenofovir: what have over 1 million years of patient experience taught us?


  • Disclosure The author has no interests which might be perceived as posing a conflict or a bias.

Anton Pozniak,
Chelsea & Westminster Hospital, Department of HIV/GU Medicine, 369 Fulham Road, London SW10 9TH, UK
Tel.: + 44 208 746 5620
Fax: + 44 208 846 6188
Email: anton.pozniak@chelwest.nhs.uk


Several groundbreaking trials and over 1 million years of patient experience have established tenofovir as an important component of HIV treatment. Tenofovir has demonstrated potent antiviral efficacy, with a low risk of developing resistance when used as part of an effective combination regimen. It is generally well tolerated, with a low risk of lipoatrophy and a favourable effect on lipid profile compared with older nucleoside analogue agents such as stavudine or zidovudine. Clinical data suggest that switching from thymidine analogues to a tenofovir-containing regimen can benefit patients with lipid abnormalities or lipoatrophy. This article reviews the development of tenofovir, including pivotal studies that have influenced HIV clinical practice.