Efficacy of low-calorie, partial meal replacement diet plans on weight and abdominal fat in obese subjects with metabolic syndrome: a double-blind, randomised controlled trial of two diet plans – one high in protein and one nutritionally balanced

Authors


  • Disclosures
    Belong Cho, MD, PhD received payment from Herbalife for lecture on obesity treatment. Other authors’ disclosure: None.

Belong Cho, MD, PhD,
Department of Family Medicine, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, Korea
Tel.: + 82 2 2072 2195
Fax: + 82 2 766 3276
Email: belong@snu.ac.kr

Abstract

Background:  Little is known about the relative efficacy of high-protein vs. conventional diet plans that include partial meal replacements on body fat loss in obese subjects with metabolic syndrome.

Objective:  We aimed to evaluate the efficacy of two low-calorie diets with partial meal replacement plans–a high-protein plan (HP) and a nutritionally balanced conventional (C) plan–on reducing obesity in obese subjects with metabolic syndrome.

Design:  In a 12-week, double-blind study, we randomised 75 participants to either the HP- or the C-plan group. We recorded key metrics at 0 and 12 weeks.

Results:  The overall mean weight loss was 5 kg in the HP-plan group and 4.9 kg in the C-plan group (p = 0.72). Truncal fat mass decreased 1.6 kg in the HP-plan group (p < 0.05) and 1.5 kg in the C-plan group (p < 0.05), while whole body fat mass decreased 2.5 kg in the HP-plan group (p < 0.05) and 2.3 kg in the C-plan group (p < 0.05). Between-group losses did not differ significantly for truncal (p = 0.52) or whole body (p = 0.77) fat mass. Among subjects with ≥ 70% dietary compliance, however, truncal and whole body fat mass decreased more in the HP-plan group (Δ2.2 kg and Δ3.5 kg respectively) than in the C-plan group (Δ1.5 kg and Δ1.9 kg respectively) (p < 0.05).

Conclusion:  The HP- and C-plans had a similar effect on weight and abdominal fat reduction, but the HP-plan was more effective in reducing body fat among compliant subjects.

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