Disclosures BSP has sat as a consultant on advisory boards for Abbott, GlaxoSmithKline and Tibotec Pharmaceuticals. ASW has received grant support, lecture honoraria and travel grants from Abbott, AstraZeneca, Fournier-Solvay, Gilead, GlaxoSmithKline, Merck kGA, Merck-Sharp & Dohme, Roche, Pfizer, Sanofi-Aventis and Takeda pharmaceuticals.
Cardiovascular risk evaluation and antiretroviral therapy effects in an HIV cohort: implications for clinical management: the CREATE 1 study
Version of Record online: 13 JUL 2010
© 2010 Blackwell Publishing Ltd
International Journal of Clinical Practice
Volume 64, Issue 9, pages 1252–1259, August 2010
How to Cite
Aboud, M., Elgalib, A., Pomeroy, L., Panayiotakopoulos, G., Skopelitis, E., Kulasegaram, R., Dimian, C., C Lampe, F., Duncan, A., Wierzbicki, A. S. and Peters, B. S. (2010), Cardiovascular risk evaluation and antiretroviral therapy effects in an HIV cohort: implications for clinical management: the CREATE 1 study. International Journal of Clinical Practice, 64: 1252–1259. doi: 10.1111/j.1742-1241.2010.02424.x
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- Issue online: 13 JUL 2010
- Version of Record online: 13 JUL 2010
- Paper received February 2010, accepted March 2010
Aims: The aim of this study is to determine the cardiovascular disease (CVD) risk profile of a large UK HIV cohort and how highly active antiretroviral therapy (HAART) affects this.
Methods: It is a cross-sectional study within a large inner city hospital and neighbouring district hospital. A total of 1021 HIV positive outpatients representative of the complete cohort and 990 who had no previous CVD were included in CVD risk analysis. We recorded demographics, HAART history and CVD risk factors. CVD and coronary heart disease (CHD) risks were calculated using the Framingham (1991) algorithm adjusted for family history.
Results: The non-CVD cohort (n = 990) was 74% men, 51% Caucasian and 73.1% were on HAART. Mean age was 41 ± 9 years, systolic blood pressure 120 ± 14 mmHg, total cholesterol 4.70 ± 1.05mmol/l, high-density lipoprotein-C 1.32 ± 0.48 mmol/l and 37% smoked. Median CVD risk was 4 (0–56) % in men and 1.4 (0–37) % in women; CHD risks were 3.5 (0–36) % and 0.6 (0–16) %. CVD risk was > 20% in 6% of men and 1% of women and > 10% in 12% of men and 4% of women. CVD risk was higher in Caucasians than other ethnicities; the risk factor contributing most was raised cholesterol. For patients on their first HAART, increased CHD risk (26.2% vs. 6.5%; odds ratio 4.03, p < 0.001) was strongly related to the duration of therapy.
Conclusions: Modifiable risk factors, especially cholesterol, and also duration of HAART, were key determinants of CVD risk.
Discussion: Regular CHD and/or CVD risk assessment should be performed on patients with HIV, especially during HAART therapy. The effect of different HAART regimens on CHD risk should be considered when selecting therapy.