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MINIREVIEW
Drug-resistant malaria − an insight
Article first published online: 30 AUG 2007
DOI: 10.1111/j.1742-4658.2007.05999.x
1742-4658/asset/cover.gif?v=1&s=fc98a9fc84ccc5e1b83463cabb40f397544364eb "FEBS Journal")
Additional Information
How to Cite
Hyde, J. E. (2007), Drug-resistant malaria − an insight. FEBS Journal, 274: 4688–4698. doi: 10.1111/j.1742-4658.2007.05999.x
Publication History
- Issue published online: 30 AUG 2007
- Article first published online: 30 AUG 2007
- (Received 6 February 2007, accepted 11 July 2007)
- Abstract
- Article
- References
- Cited By
Keywords:
- antifolates;
- artemisinins;
- atovaquone;
- chloroquine;
- combination therapy;
- gene copy number;
- gene polymorphisms;
- Plasmodium falciparum
Despite intensive research extending back to the 1930s, when the first synthetic antimalarial drugs made their appearance, the repertoire of clinically licensed formulations remains very limited. Moreover, widespread and increasing resistance to these drugs contributes enormously to the difficulties in controlling malaria, posing considerable intellectual, technical and humanitarian challenges. A detailed understanding of the molecular mechanisms underlying resistance to these agents is emerging that should permit new drugs to be rationally developed and older ones to be engineered to regain their efficacy. This review summarizes recent progress in analysing the causes of resistance to the major antimalarial drugs and its spread.