• 1
    Goldberg Y (1999) Protein phosphatase 2A: who shall regulate the regulator? Biochem Pharmacol 57, 321328.
  • 2
    Zolnierowicz S (2000) Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. Biochem Pharmacol 60, 12251235.
  • 3
    Zabrocki P, Van Hoof C, Goris J, Thevelein JM, Winderickx J & Wera1 S (2002) Protein phosphatase 2A on track for nutrient-induced signalling in yeast. Mol Microbiol 43, 835842.
  • 4
    Cohen PT, Philp A & Vazquez-Martin C (2005) Protein phosphatase 4 – from obscurity to vital functions. FEBS Lett 579, 32783286.
  • 5
    Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B & Aebersold R (2005) A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Mol Cell Proteomics 4, 17251740.
  • 6
    Stefansson B & Brautigan DL (2006) Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IκBε. J Biol Chem 281, 2262422634.
  • 7
    Murata K, Wu J & Brautigan DL (1997) B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A. Proc Natl Acad Sci USA 94, 1062410629.
  • 8
    Inui S, Sanjo H, Maeda K, Yamamoto H, Miyamoto E & Sakaguchi N (1998) Ig receptor binding protein 1 (α4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A. Blood 92, 539546.
  • 9
    Nanahoshi M, Nishiuma T, Tsujishita Y, Hara K, Inui S, Sakaguchi N & Yonezawa K (1998) Regulation of protein phosphatase 2A catalytic activity by α4 protein and its yeast homolog Tap42. Biochem Biophys Res Commun 251, 520526.
  • 10
    Nanahoshi M, Tsujishita Y, Tokunaga C, Inui S, Sakaguchi N, Hara K & Yonezawa K (1999) α4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases. FEBS Lett 446, 108112.
  • 11
    Kuwahara K, Matsuo T, Nomura J, Igarashi H, Kimoto M, Inui S & Sakaguchi N (1994) Identification of a 52-kDa molecule (p52) coprecipitated with the Ig receptor-related MB-1 protein that is inducibly phosphorylated by the stimulation with phorbol myristate acetate. J Immunol 152, 27422752.
  • 12
    Inui S, Maeda K, Hua DR, Yamashita T, Yamamoto H, Miyamoto E, Aizawa S & Sakaguchi N (2002) BCR signal through α4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation. Int Immunol 14, 177187.
  • 13
    Hua DR, Inui S, Yamashita T, Maeda K, Takagi K, Takeda J & Sakaguchi N (2003) T cell-specific gene targeting reveals that α4 is required for early T cell development. Eur J Immunol 33, 18991906.
  • 14
    Kong M, Fox CJ, Mu J, Solt L, Xu A, Cinalli RM, Birnbaum MJ, Lindsten T & Thompson CB (2004) The PP2A-associated protein α4 is an essential inhibitor of apoptosis. Science 306, 695698.
  • 15
    Liu J, Prickett TD, Elliott E, Meroni G & Brautigan DL (2001) Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit α4. Proc Natl Acad Sci USA 98, 66506655.
  • 16
    Trockenbacher A, Suckow V, Foerster J, Winter J, Krauss S, Ropers HH, Schneider R & Schweiger S (2001) MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation. Nat Genet 29, 287294.
  • 17
    Yamashita T, Inui S, Maeda K, Hua DR, Takagi K & Sakaguchi N (2005) The heterodimer of α4 and PP2Ac is associated with S6 kinase1 in B cells. Biochem Biophys Res Commun 330, 439445.
  • 18
    Yamashita T, Inui S, Maeda K, Hua DR, Takagi K, Fukunaga K & Sakaguchi N (2006) Regulation of CaMKII by α4/PP2Ac contributes to learning and memory. Brain Res 1082, 110.
  • 19
    Di Como CJ & Arndt KT (1996) Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev 10, 19041916.
  • 20
    Jacinto E, Guo B, Arndt KT, Schmelzle T & Hall MN (2001) TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Mol Cell 8, 10171026.
  • 21
    Fenyvuesvolgyi C, Elder RT, Benko Z, Liang D & Zhao RY (2005) Fission yeast homologue of Tip41-like proteins regulates type 2A phosphatases and responses to nitrogen sources. Biochim Biophys Acta 1746, 155162.
  • 22
    Zanchin NI & Goldfarb DS (1999) Nip7p interacts with Nop8p, an essential nucleolar protein required for 60S ribosome biogenesis, and the exosome subunit Rrp43p. Mol Cell Biol 19, 15181525.
  • 23
    Zhou Y, Zhang X & Ebright RC (1991) Random mutagenesis of gene-sized DNA molecules by use of PCR with Taq DNA polymerase. Nucleic Acids Res 19, 6052.
  • 24
    Smetana JH, Oliveira CL, Jablonka W, Aguiar Pertinhez T, Carneiro FR, Montero-Lomeli M, Torriani I & Zanchin NI (2006) Low resolution structure of the human α4 protein (IgBP1) and studies on the stability of α4 and of its yeast ortholog Tap42. Biochim Biophys Acta 1764, 724734.
  • 25
    Kloeker S, Reed R, McConnell JL, Chang D, Tran K, Westphal RS, Law BK, Colbran RJ, Kamoun M, Campbell KS et al. (2003) Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with α4 protein. Protein Expr Purif 31, 1933.
  • 26
    Prickett TD & Brautigan DL (2004) Overlapping binding sites in protein phosphatase 2A for association with regulatory A and α-4 (mTap42) subunits. J Biol Chem 279, 3891238920.
  • 27
    Prickett TD & Brautigan DL (2006) The α4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A. J Biol Chem 281, 3050330511.
  • 28
    Chen J, Peterson RT & Schreiber SL (1998) α4 associates with protein phosphatases 2A, 4, and 6. Biochem Biophys Res Commun 247, 827832.
  • 29
    Ogris E, Gibson DM & Pallas DC (1997) Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen. Oncogene 15, 911917.
  • 30
    Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD & Shi Y (2006) Structure of the protein phosphatase 2A holoenzyme. Cell 127, 12391251.
  • 31
    Cho US & Xu W (2007) Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme. Nature 445 (7123), 5357.
  • 32
    McConnell JL, Gomez RJ, McCorvey LR, Law BK & Wadzinski BE (2007) Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway. Oncogene 26, 60216030.
  • 33
    Ly C, Arechiga AF, Melo JV, Walsh CM & Ong ST (2003) Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. Cancer Res 63, 57165722.
  • 34
    Carneiro FR, Silva TC, Alves AC, Haline-Vaz T, Gozzo FC & Zanchin NI (2006) Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1. Biochem Biophys Res Commun 343, 260268.
  • 35
    Ausubel FM, Brent R, Kingston R, Moore DD, Seidman JG, Smith JA & Struhl K (1998) Current Protocols in Molecular Biology. Wiley, New York.