• 1
    Ono Y, Fujii T, Ogita K, Kikkawa U, Igarashi K & Nishizuka Y (1988) The structure, expression, and properties of additional members of the protein kinase C family. J Biol Chem 263, 69276932.
  • 2
    Westel WC, Khan WA, Merchenthaler I, Rivera H, Halpern AE, Phung HM, Negro-Vilar A & Hannun YA (1992) Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J Cell Biol 117, 121133.
  • 3
    Koide H, Ogita K, Kikkawa U & Nishizuka Y (1992) Isolation and characterization of the ε subspecies of protein kinase C from rat brain. Proc Natl Acad Sci USA 89, 11491153.
  • 4
    Saito N, Itouji A, Totani Y, Osawa I, Koide H, Fujisawa N, Ogita K & Tanaka C (1993) Cellular and intracellular localization of e-subspecies of protein kinase C in the rat brain; presynaptic localization of the e-subspecies. Brain Res 607, 241248.
  • 5
    Tanaka C & Nishizuka Y (1994) The protein kinase C family for neural signaling. Annu Rev Neurosci 17, 551567.
  • 6
    Hundle B, McMahon T, Dagar J & Messing RO (1995) Overexpression of ε-protein kinase C enhances nerve growth factor-induced phosphorylation of mitogen-activated protein kinases and neurite outgrowth. J Biol Chem 270, 3013430140.
  • 7
    Zeidman R, Lofgren B, Pahlman S & Larsson C (1999) PKCε, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells. J Cell Biol 145, 713726.
  • 8
    Zeidman R, Troller U, Raghunath A, Pahlman S & Larsson C (2002) Protein kinase Cε actin-binding site is important for neurite outgrowth during neuronal differentiation. Mol Biol Cell 13, 1224.
  • 9
    Lingm M, Troller U, Zeidman R, Lundberg C & Larsson C (2004) Induction of neurites by the regulatory domains of PKCδ and ε is counteracted by PKC catalytic activity and by the RhoA pathway. Exp Cell Res 292, 135150.
  • 10
    Troller U & Larsson C (2006) Cdc42 is involved in PKCε- and δ-induced neurite outgrowth and stress fibre dismantling. Biochem Biophys Res Commun 349, 9198.
  • 11
    Shirai Y, Murakami T, Kuramasu M, Iijima L & Saito N (2007) A novel PIP2 binding of εPKC and its contribution to the nerutite induction ability. J Neurochem 102, 16351644.
  • 12
    Faure J, Vignais PV & Dagher MC (1999) Phosphoinositide-dependent activation involves partial opening of the RhoA/Rho-GDI complex. Eur J Biochem 262, 879889.
  • 13
    Troller U & Larsson C (2004) A possible role for p190RhoGAP in PKCε-induced morphological effects. Cellular Sigmal 16, 245252.
  • 14
    Lingm M, Troller U, Zeidman R, Stensman H, Schultz A & Larssonm C (2005) Identification of conserved amino acids N-terminal of the PKCεC1b domain crucial for protein kinase Ce-mediated induction of neurite outgrowth. J Cell Biol 280, 1791017919.
  • 15
    Hussain RJ & Carpenter DO (2005) A comparison of the roles of protein kinase C in long-term potentiation in rat hippocampal areas CA1 and CA3. Cell Mol Neurobiol 25, 649661.
  • 16
    Saito N & Shirai Y (2002) Protein kinase Cγ (PKCγ): function of neuron specific isotype. J Biochem 132, 683687.
  • 17
    Saitoh N, Hori T & Takahashi T (2001) Activation of the epsilon isoform of protein kinase C in the mammalian nerve terminal. Proc Natl Acad Sci USA 98, 1401714021.
  • 18
    Prekeris R, Mayhew MW, Cooper JB & Terrian DM (1996) Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and paraticipates in the regulation of synapitic function. J Cell Biol 132, 7790.
  • 19
    Dumus A, Sebben M & Haynes L (1988) NMDA receptors activate the arachidnic acid cascade system in striatal neurons. Nature 336, 6870.
  • 20
    Kasahara K & Kikkawa U (1995) Distinct effects of saturated fatty acids on protein kinase C subspecies. J Biochem 117, 648653.
  • 21
    Hama H, Hara Chikako, Kazuhiko Yamaguchi & Miyawaki A (2004) PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggers by local contact with astrocytes. Neuron 41, 405415.
  • 22
    Gordon AS, Yao L, Wu Z, Coe IR & Diamond I (1997) Ethanol alters the subcellular localization of δ- and ε-protein kinase C in NG108-15 cells. Mol Pharmacol 52, 554559.
  • 23
    Messing RO, Petersen PJ & Henrich CJ (1991) Chronic ethanol exposure increases level of protein kinase Cδ and ε and protein kinase mediated phosphorylation in cultured neural cells. J Biol Chem 266, 2342823432.
  • 24
    Coe IR, Yao L, Diamond I & Gordon AS (1996) The role of protein kinase C in cellular tolerance to ethanol. J Biol Chem 271, 2946829472.
  • 25
    Hodge CW, Mehmert KK, Kelly SP, McMahon T, Haywood A, Olive MF, Wang D, Sanchez-Perez AM & Messig RO (1999) Suppersensitivity to allosteric GABAA receptor modulators and alcohol in mice lacking PKCε. Nat Neurosci 2, 9971002.
  • 26
    Choi DS, Jahan DW, Dadgar J, Chang WS & Messing RO (2002) Conditional rescue of protein kinase Cε regulates ethanol preference and hypnotic sensitivity in adult mice. J Neurosci 22, 99059911.
  • 27
    Qi ZH, Song M, Wallace MJ, Wang D, Newton PM, MaMahon T, Chou WH, Zhang C, Shokat KM & Messing RO (2007) Protein kinase C epsilon regulates GABAA receptor sensitivity to ethanol and bendodiazepines through phosphorylation of γ2 subunits. J Biol Chem 282, 3305233063.
  • 28
    Mcmahon T, Andersen R, Metten P, Crabbe JC & Messing RO (2000) Protein kinase Cε mediates up-regulation of N-type calcium channels by ethanol. Mol Pharmacol 57, 5358.
  • 29
    Armstrong SC (2004) Protein kinase activation and myocardial ischemia/reperfusion injury. Cardiov Res 61, 427436.
  • 30
    Chou WH & Messing RO (2005) Protein kinase C isozymes in stroke. TCM 15, 4751.
  • 31
    Murriel CL & Mochly-Rosen D (2003) Opposing roles of δ and εPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery. Arc Biochem Biophys 420, 246254.
  • 32
    Saurin AT, Pennington DJ, Raat NJH, Latchman DS, Owen MJ & Marber M (2002) Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischemic preconditioning of isolated buffer-perfusion mouse hearts. Cardiov Res 55, 672680.
  • 33
    Raval AP, Dave KR, Mochly-Rosen D, Sick TJ & Perez-Pinzon MA (2003) εPKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice. J Neuroscience 23, 384391.
  • 34
    Lange-Asschenfeldt C, Raval AP, Dave KR, Mochly-Rosen D, Sick TJ & Perez-Pinzon MA (2004) Epsilon protein kinase C mediated ischemic tolerance requires activation of the extracellular regulated kinase pathway in the orgonotypic hippocampal slice. J Cereb Blood Flow Metab 24, 636645.
  • 35
    Wang J, Bright R, Mochly-Rosen D & Giffard RG (2004) Cell-specific role for ε- and βI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury. Neuropharmacology 47, 136145.
  • 36
    Di-Capua N, Sperling O & Zoref-Shani E (2003) Protein kinase C-ε is involved in the adenosine-activated signal transduction pathway conferring protection against ischemia-reperfusion injury in primary rat neuronal cultures. J Neurochem 84, 409412.
  • 37
    Shimomura T, Zhao H & Steinberg GK (2007) εPKC may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia model. Stroke 38, 375380.
  • 38
    Davis J, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K et al. (2000) Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405, 183187.
  • 39
    Premkumar LS & Ahern GP (2000) Induction of vanilloid receptor channel activity by protein kinase C. Nature 408, 985990.
  • 40
    Tominaga M, Wada M & Masu M (2001) Poteintiation of capsaicin receptor activity by metanotropic ATP receptor as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc Natl Acad Sci USA 98, 69516956.
  • 41
    Numazaki M, Tominaga T, Toyooka H & Tominaga M (2002) Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cε and identification of two target serine residues. J Biol Chem 277, 1337513378.
  • 42
    Mandadi S, Tominaga T, Numazaki M, Murayama N, Saito N, Armati PJ, Roufogails B & Tominaga M (2006) Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCε-mediated phosphorylation at S800. Pain 123, 106116.
  • 43
    Dai Y, Moriyama T, Higashi T, Togashi K, Kobayashi K, Yamanaka H, Tominaga M & Noguchi K (2004) Proteinase-activated receptor2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. J Neurosci 24, 42984299.
  • 44
    Chen Y, Cantrell AR, Messinbg RO, Sceuer T & Catterall WA (2005) Specific modulation of Na+ channels in hippocampal neurons by protein kinase Cε. J Neurosci 25, 507513.
  • 45
    Zhu G, Wang D, Lin YH, McMahon T, Koo EH & Messing RO (2001) Protein kinase C ε suppresses Aβ production and promotes activation of α-secretase. Biochem Bioohys Res Commun 285, 9971006.
  • 46
    Choi DS, Wang D, Yu GQ, Zhu G, Kharazia VN, Paredes JP, Chang WS, Deitchman JK, Mucke L & Messing RO (2006) PKCe increases endothelin convertinbg enzyme activity and reuduces amyloid plaque pathology in transgenic mice. Proc Natl Acad Sci USA 103, 82158220.
  • 47
    Steinhart R, Kazimirsky G, Okhrimenko H, Ben-Hur T & Broudei C (2007) PKCε induces astrocytes differentiation of multipotential neural precursor cells. Glia 55, 224232.
  • 48
    Akita Y (2002) Protein kinase Cε (PKC-ε): its unique structure and function. J Biochem 132, 847852.
  • 49
    Proctor WR, Poelchen W, Bowers BJ, Wehner JM, Messiing RO & Dunwiddie TV (2003) Ethanol differentially enhances hippocampal GABAA receptor mediated responses in protein kinase Cγ (PKCγ) ans PKCε null mice. J Pharmacol Exp Ther 305, 264270.