Systems biology: parameter estimation for biochemical models

Authors


J. G. Blom, Centrum voor Wiskunde en Informatica, Science Park 123, 1098 XG Amsterdam, The Netherlands
Fax: +31 20 5924199
Tel: +31 20 5924263
E-mail: joke.blom@cwi.nl

Abstract

Mathematical models of biological processes have various applications: to assist in understanding the functioning of a system, to simulate experiments before actually performing them, to study situations that cannot be dealt with experimentally, etc. Some parameters in the model can be directly obtained from experiments or from the literature. Others have to be inferred by comparing model results to experiments. In this minireview, we discuss the identifiability of models, both intrinsic to the model and taking into account the available data. Furthermore, we give an overview of the most frequently used approaches to search the parameter space.

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